产品
编 号：F360614
分子式：C23H25NO8S3
分子量：539.64
分子式：C23H25NO8S3
分子量：539.64
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 447459-51-0
产品详情
生物活性：
SCH 336 is a potent, selective, inverse and orally active CB2 agonist. SCH 336 inhibits BaF3/CB2 migration. SCH 336 significantly inhibits the migration of leukocytes in vivo. SCH 336 blocks ovalbumin-induced lung eosinophilia in mice.
体内研究：
SCH 336 (0.02, 0.2, 2.0 mg/kg; i.p.) significantly inhibits the migration of leukocytes.Animal Model:Female B6D2/F1 mice (HU210)
Dosage:0.02, 0.2, 2.0 mg/kg
Administration:I.p.
Result:Significantly inhibited the migration of leukocytes into the CCL2-soaked gel foam sponge.
体外研究：
SCH 336 (Sch.336) (0-10 μM) competes with [3H]CP55,940 for binding to human CB2 on Sf9 cell membranes with Ki of 1.8 nM, and decreases GTPγS binding on human CB2-containing membranes with an EC50 of 2 nM, decreases potency on CB1-containing membranes with EC50 of 200 nM.SCH 336 inhibits BaF3/CB2 migration to 100 nM 2-AG with an IC50 of 34 nM.
SCH 336 is a potent, selective, inverse and orally active CB2 agonist. SCH 336 inhibits BaF3/CB2 migration. SCH 336 significantly inhibits the migration of leukocytes in vivo. SCH 336 blocks ovalbumin-induced lung eosinophilia in mice.
体内研究：
SCH 336 (0.02, 0.2, 2.0 mg/kg; i.p.) significantly inhibits the migration of leukocytes.Animal Model:Female B6D2/F1 mice (HU210)
Dosage:0.02, 0.2, 2.0 mg/kg
Administration:I.p.
Result:Significantly inhibited the migration of leukocytes into the CCL2-soaked gel foam sponge.
体外研究：
SCH 336 (Sch.336) (0-10 μM) competes with [3H]CP55,940 for binding to human CB2 on Sf9 cell membranes with Ki of 1.8 nM, and decreases GTPγS binding on human CB2-containing membranes with an EC50 of 2 nM, decreases potency on CB1-containing membranes with EC50 of 200 nM.SCH 336 inhibits BaF3/CB2 migration to 100 nM 2-AG with an IC50 of 34 nM.
产品资料
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