产品
编 号：F359589
分子式：C6H9N3O3
分子量：171.15
分子式：C6H9N3O3
分子量：171.15
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
280
In-stock
5g
360
In-stock
10g
640
In-stock
结构图
CAS No: 443-48-1
产品详情
生物活性：
Metronidazole is an orally active nitroimidazole antibiotic. Metronidazole can cross blood brain barrier. Metronidazole can be used for the research of anaerobic infections.
体内研究：
Metronidazole (135 mg/kg/d; p.o.; 28 d) can cross the blood brain barrier, and exhibits neurotoxicity under long term administration in rats.Metronidazole (1 g/L; p.o.; 4 weeks) results skeletal muscle atrophy and changes the expression of genes involved in the muscle peripheral circadian rhythm machinery and metabolic regulation.Animal Model:Sprague-Dawley (SD) rats (200-220 g)
Dosage:135 mg/kg
Administration:Oral gavage; once daily; 28 days
Result:Caused inflammatory markers increasing, including iNOS, eNOS, Bax and caspase 3 protein expressions increasing and caused oxidative stress damage in brain tissue, with MDA content rising.
Animal Model:SPF C57Bl/6J mice (6-7 months old)
Dosage:1 g/L
Administration:Oral gavage; provided with drinking water for 4 weeks, changed twice weekly
Result:Resulted the muscle core clock and effector genes Cry2, Ror-β, E4BP4, PP ARγ and adiponectin expression increasing. Decreased hind limb muscle weight and resulted in smaller fibers in the tibialis anterior muscle.
体外研究：
Metronidazole displays inhibitory activity towards anaerobic protozoa Trichomonas vaginalis, Entamoeba histolytica, Giardia lamblia, and Balantidium coli.Metronidazole (4-8 μg/mL) inhibits anaerobic bacteria and shows good bactericidal activity.Metronidazole (0.1 μg/mL-0.01 mg/mL; 12-96 h) induces granular formation and triggers apoptosis in Blastocystis sp.
Metronidazole is an orally active nitroimidazole antibiotic. Metronidazole can cross blood brain barrier. Metronidazole can be used for the research of anaerobic infections.
体内研究：
Metronidazole (135 mg/kg/d; p.o.; 28 d) can cross the blood brain barrier, and exhibits neurotoxicity under long term administration in rats.Metronidazole (1 g/L; p.o.; 4 weeks) results skeletal muscle atrophy and changes the expression of genes involved in the muscle peripheral circadian rhythm machinery and metabolic regulation.Animal Model:Sprague-Dawley (SD) rats (200-220 g)
Dosage:135 mg/kg
Administration:Oral gavage; once daily; 28 days
Result:Caused inflammatory markers increasing, including iNOS, eNOS, Bax and caspase 3 protein expressions increasing and caused oxidative stress damage in brain tissue, with MDA content rising.
Animal Model:SPF C57Bl/6J mice (6-7 months old)
Dosage:1 g/L
Administration:Oral gavage; provided with drinking water for 4 weeks, changed twice weekly
Result:Resulted the muscle core clock and effector genes Cry2, Ror-β, E4BP4, PP ARγ and adiponectin expression increasing. Decreased hind limb muscle weight and resulted in smaller fibers in the tibialis anterior muscle.
体外研究：
Metronidazole displays inhibitory activity towards anaerobic protozoa Trichomonas vaginalis, Entamoeba histolytica, Giardia lamblia, and Balantidium coli.Metronidazole (4-8 μg/mL) inhibits anaerobic bacteria and shows good bactericidal activity.Metronidazole (0.1 μg/mL-0.01 mg/mL; 12-96 h) induces granular formation and triggers apoptosis in Blastocystis sp.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备