产品
编 号：F359495
分子式：C22H14O9
分子量：422.34
分子式：C22H14O9
分子量：422.34
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
440
In-stock
结构图
CAS No: 4431-00-9
产品详情
生物活性：
Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively. Aurintricarboxylic acid is a potent anti-influenza agent by directly inhibiting the neuraminidase. Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis. Aurintricarboxylic acid is a selective inhibitor of the TWEAK-Fn14 signaling pathway. Aurintricarboxylic acid also acts as a cystathionine-lyase (CSE) inhibitor with an IC50 of 0.6 μM. Aurintricarboxylic acid is a modifier of miRNAs that regulate miRNA function, with an IC50 of 0.47 μM.
体外研究：
Aurintricarboxylic acid 弱抑制 P2X2/3Rs、P2X2Rs、P2X4Rs 或 P2X7Rs。 Aurintricarboxylic acid 以浓度依赖性方式抑制 ATP 诱导的电流。通过抑制神经氨酸酶活性。 Aurintricarboxylic acid 抑制TWEAK-Fn14介导的NF-κB激活。 Aurintricarboxylic acid (10 μM；0.5-2 小时) 抑制 GBM 细胞中 TWEAK-Fn14 介导的 NF-κB、Akt 和 Src 磷酸化。 Aurintricarboxylic acid 抑制 TWEAK 刺激的神经胶质瘤细胞迁移和侵袭而不会引起细胞毒性。 Aurintricarboxylic acid (化合物8) 不能调节培养细胞内内源性 let-7 加载到 AGO2 上，而可以抑制 RISC 加载外源 siRNA。
Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively. Aurintricarboxylic acid is a potent anti-influenza agent by directly inhibiting the neuraminidase. Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis. Aurintricarboxylic acid is a selective inhibitor of the TWEAK-Fn14 signaling pathway. Aurintricarboxylic acid also acts as a cystathionine-lyase (CSE) inhibitor with an IC50 of 0.6 μM. Aurintricarboxylic acid is a modifier of miRNAs that regulate miRNA function, with an IC50 of 0.47 μM.
体外研究：
Aurintricarboxylic acid 弱抑制 P2X2/3Rs、P2X2Rs、P2X4Rs 或 P2X7Rs。 Aurintricarboxylic acid 以浓度依赖性方式抑制 ATP 诱导的电流。通过抑制神经氨酸酶活性。 Aurintricarboxylic acid 抑制TWEAK-Fn14介导的NF-κB激活。 Aurintricarboxylic acid (10 μM；0.5-2 小时) 抑制 GBM 细胞中 TWEAK-Fn14 介导的 NF-κB、Akt 和 Src 磷酸化。 Aurintricarboxylic acid 抑制 TWEAK 刺激的神经胶质瘤细胞迁移和侵袭而不会引起细胞毒性。 Aurintricarboxylic acid (化合物8) 不能调节培养细胞内内源性 let-7 加载到 AGO2 上，而可以抑制 RISC 加载外源 siRNA。
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