产品
编 号：F358131
分子式：C15H20ClNO4
分子量：313.78
分子式：C15H20ClNO4
分子量：313.78
产品类型
规格
价格
是否有货
100μg
询价
询价
500μg
询价
询价
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 437742-34-2
产品详情
生物活性：
Marizomib (Salinosporamide A) is a second-generation, irreversible, brain-penetrant, pan-proteasome inhibitor. Marizomib inhibits the CT-L (β5), CT-T-laspase-like (C-L, β1) and trypsin-like (T-L, β2) activities of the 20S proteasome (IC50=3.5, 28, and 430 nM, respectively).
体内研究：
Marizomib (Salinosporamide A) (0.15 mg/kg; i.v; twice a week for three weeks) significantly decreases tumor growth, and is not associated with any toxicity.Animal Model:CB-17 SCID-male mice (4-6 weeks old)
Dosage:0.15 mg/kg
Administration:i.v; twice a week for three weeks
Result:Significantly decreased tumor growth, and was not associated with any toxicity.
体外研究：
Marizomib (Salinosporamide A) (0.1-10000 nM; 72 hours) effectively reduces survival of D-54 and U-251 cells in a dose-dependent manner. The IC50s are ～52 nM for U-251 and ～20 nM for D-54.?Marizomib (24 hours; 60 nM) induces apoptosis and caspase-3 activation in glioma cells.
Marizomib (Salinosporamide A) is a second-generation, irreversible, brain-penetrant, pan-proteasome inhibitor. Marizomib inhibits the CT-L (β5), CT-T-laspase-like (C-L, β1) and trypsin-like (T-L, β2) activities of the 20S proteasome (IC50=3.5, 28, and 430 nM, respectively).
体内研究：
Marizomib (Salinosporamide A) (0.15 mg/kg; i.v; twice a week for three weeks) significantly decreases tumor growth, and is not associated with any toxicity.Animal Model:CB-17 SCID-male mice (4-6 weeks old)
Dosage:0.15 mg/kg
Administration:i.v; twice a week for three weeks
Result:Significantly decreased tumor growth, and was not associated with any toxicity.
体外研究：
Marizomib (Salinosporamide A) (0.1-10000 nM; 72 hours) effectively reduces survival of D-54 and U-251 cells in a dose-dependent manner. The IC50s are ～52 nM for U-251 and ～20 nM for D-54.?Marizomib (24 hours; 60 nM) induces apoptosis and caspase-3 activation in glioma cells.
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