产品
编 号：F358065
分子式：C21H25ClN2O3
分子量：388.89
分子式：C21H25ClN2O3
分子量：388.89
产品类型
规格
价格
是否有货
结构图
CAS No: 4373-34-6
产品详情
生物活性：
Ajmalicine (Raubasine) hydrochloride is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine hydrochloride is an reversible but non-competitive nicotine receptor full inhibitor, with an IC50 of 72.3 μM. Ajmalicine hydrochloride also can be used as anti-hypertensive, and serpentine, with sedative activity.
体内研究：
Ajmalicine hydrochloride blocking the pressor action of electrical stimulation and is active against sympathetic stimulation.Ajmalicine hydrochloride (0.5-4 mg/kg) induces a marked dose-dependent inhibition against the pressor response to noradrenaline.Animal Model:Male Wistar rats (300-350 g)
Dosage:0.5, 1, 2, and 4 mg/kg
Administration:IV, once
Result:Induced a marked dose-dependent inhibition against the pressor response to noradrenaline.
体外研究：
Ajmalicine hydrochloride preferentially blocks α1-adrenoceptor than α2-adrenoceptor.Ajmalicine hydrochloride inhibits contractions in a concentration-dependent manner (IC50=72.3 ± 22.5 μM).Ajmalicine hydrochloride acts preferentially at postsynaptic sites, competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptor with a pA2 value of 6.57, blocks the inhibitory effect of clonidine with an pA2 value of 6.2.
Ajmalicine (Raubasine) hydrochloride is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine hydrochloride is an reversible but non-competitive nicotine receptor full inhibitor, with an IC50 of 72.3 μM. Ajmalicine hydrochloride also can be used as anti-hypertensive, and serpentine, with sedative activity.
体内研究：
Ajmalicine hydrochloride blocking the pressor action of electrical stimulation and is active against sympathetic stimulation.Ajmalicine hydrochloride (0.5-4 mg/kg) induces a marked dose-dependent inhibition against the pressor response to noradrenaline.Animal Model:Male Wistar rats (300-350 g)
Dosage:0.5, 1, 2, and 4 mg/kg
Administration:IV, once
Result:Induced a marked dose-dependent inhibition against the pressor response to noradrenaline.
体外研究：
Ajmalicine hydrochloride preferentially blocks α1-adrenoceptor than α2-adrenoceptor.Ajmalicine hydrochloride inhibits contractions in a concentration-dependent manner (IC50=72.3 ± 22.5 μM).Ajmalicine hydrochloride acts preferentially at postsynaptic sites, competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptor with a pA2 value of 6.57, blocks the inhibitory effect of clonidine with an pA2 value of 6.2.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备