产品
编 号：F357384
分子式：C111H149N27O28
分子量：2309.53
分子式：C111H149N27O28
分子量：2309.53
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 433922-67-9
产品详情
生物活性：
Edratide (TV 4710) is a synthetic peptide of 19 amino acid based on the complementarity-determining region 1 (CDR1) of a human anti-DNA antibody that expresses a major idiotype denoted 16/6 Id. Edratide reduces the rates of apoptosis (Apoptosis) and down-regulates of caspase-8 and caspase-3, up-regulates Bcl-xL. Edratide has the potential for the research of systemic lupus erythematosus (SLE).
体内研究：
Edratide (20-50 μg; s.c.; once a week for 10 weeks) exerts beneficial effects on SLE is through regulation of gene expression.Edratide (50 μg/mouse; s.c.; 10 weekly) reduces the rates of apoptosis and down-regulates of caspase-8 and caspase-3, up-regulates Bcl-xL in SLE mouse.Animal Model:6-7 months female mice (with established SLE)
Dosage:20-50 μg
Administration:Subcutaneously injection; once a week for 10 weeks
Result:Up-regulated the RNA transcripts of Tnfsf4, Il5ra, Zbtb20, Nid1, down-regulated the transcripts of Tfpi and S100a8.
Animal Model:7-8 months SLE-afflicted BWF1 female mice
Dosage:50 μg/mouse
Administration:S.c.; 10 weekly
Result:Reduced apoptosis, down-regulated caspase-8 and caspase-3, and up-regulated Bcl-xL.
Edratide (TV 4710) is a synthetic peptide of 19 amino acid based on the complementarity-determining region 1 (CDR1) of a human anti-DNA antibody that expresses a major idiotype denoted 16/6 Id. Edratide reduces the rates of apoptosis (Apoptosis) and down-regulates of caspase-8 and caspase-3, up-regulates Bcl-xL. Edratide has the potential for the research of systemic lupus erythematosus (SLE).
体内研究：
Edratide (20-50 μg; s.c.; once a week for 10 weeks) exerts beneficial effects on SLE is through regulation of gene expression.Edratide (50 μg/mouse; s.c.; 10 weekly) reduces the rates of apoptosis and down-regulates of caspase-8 and caspase-3, up-regulates Bcl-xL in SLE mouse.Animal Model:6-7 months female mice (with established SLE)
Dosage:20-50 μg
Administration:Subcutaneously injection; once a week for 10 weeks
Result:Up-regulated the RNA transcripts of Tnfsf4, Il5ra, Zbtb20, Nid1, down-regulated the transcripts of Tfpi and S100a8.
Animal Model:7-8 months SLE-afflicted BWF1 female mice
Dosage:50 μg/mouse
Administration:S.c.; 10 weekly
Result:Reduced apoptosis, down-regulated caspase-8 and caspase-3, and up-regulated Bcl-xL.
产品资料
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