产品
编 号：F357110
分子式：C15H13N3O2S
分子量：299.35
分子式：C15H13N3O2S
分子量：299.35
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
320
In-stock
500mg
640
In-stock
结构图
CAS No: 43210-67-9
产品详情
生物活性：
Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent and acts on helminthes primarily by binding to tubulin and disrupting the tubulin microtubule equilibrium. Fenbendazole stabilizes the transcriptional activator HIF-1α. Fenbendazole possesses an efficient anti-proliferative activity and induces apoptosis. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53.
体内研究：
芬苯达唑 (1 mg; 口服; 每隔一天一次; 持续 12 天) 可显着减小肿瘤大小和重量。Animal Model:Female athymic nu/nu mice were xenografted with A549 cells
Dosage:1?mg/mouse
Administration:Orally; every second day for 12 day
Result:Led to a marked reduction in tumour size and weight. Led to a reduction in hemoglobin content in tumors signifying reduced tumor vascularity.
体外研究：
芬苯达唑 (1 uM; 24 小时) 在野生型 p53 的人非小细胞肺癌 (NSCLC) 的肿瘤细胞系 (H460 和 A549) 中显着抑制细胞生长。 芬苯达唑 (1 uM; 24 小时) 诱导细胞凋亡并导致线粒体 p53 蛋白水平升高。芬苯达唑 (1 uM; 24 小时) 可以引起人 NSCLC 细胞的有丝分裂期细胞的周期停滞。芬苯达唑 (1 uM; 24 小时) 可以导致 A549 细胞微管网络的部分改变。
Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent and acts on helminthes primarily by binding to tubulin and disrupting the tubulin microtubule equilibrium. Fenbendazole stabilizes the transcriptional activator HIF-1α. Fenbendazole possesses an efficient anti-proliferative activity and induces apoptosis. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53.
体内研究：
芬苯达唑 (1 mg; 口服; 每隔一天一次; 持续 12 天) 可显着减小肿瘤大小和重量。Animal Model:Female athymic nu/nu mice were xenografted with A549 cells
Dosage:1?mg/mouse
Administration:Orally; every second day for 12 day
Result:Led to a marked reduction in tumour size and weight. Led to a reduction in hemoglobin content in tumors signifying reduced tumor vascularity.
体外研究：
芬苯达唑 (1 uM; 24 小时) 在野生型 p53 的人非小细胞肺癌 (NSCLC) 的肿瘤细胞系 (H460 和 A549) 中显着抑制细胞生长。 芬苯达唑 (1 uM; 24 小时) 诱导细胞凋亡并导致线粒体 p53 蛋白水平升高。芬苯达唑 (1 uM; 24 小时) 可以引起人 NSCLC 细胞的有丝分裂期细胞的周期停滞。芬苯达唑 (1 uM; 24 小时) 可以导致 A549 细胞微管网络的部分改变。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备