产品
编 号：F356653
分子式：C16H16O4
分子量：272.3
分子式：C16H16O4
分子量：272.3
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 43043-74-9
产品详情
生物活性：
Deoxyshikonin increases the expression of VEGF-C and VEGF-A mRNA in HMVEC-dLy, promotes HIF-1α and HIF-1β subunit interaction and binds to specific DNA sequences targeted by HIF. Deoxyshikonin inhibited colorectal cancer (CRC) through the PI3K/Akt/mTOR pathway. Deoxyshikonin has proangiogenesis effect and antitumor activity. Deoxyshikonin is an antibacterial agent against methicillin-resistant S. aureus (MRSA) and S. pneumonia (MIC=17 μg/mL).
体内研究：
Deoxyshikonin (20mg/kg；腹腔注射；每两天一次，持续 13 天) 以 20 mg/kg 剂量在第 5、9 和 11 天，显着抑制异种移植肿瘤的生长。Animal Model:Male BALB/c nude mice of 10-14?g with DLD-1 cells
Dosage:20?mg/kg
Administration:Intraperitoneal injection; every two days for a total of 13 days
Result:Markedly suppressed the growth of xenograft tumours on day 5, 9 and 11 with 20?mg/kg, while there were no significant changes in body weight of the mice.
体外研究：
Deoxyshikonin (6.25-100?μg/mL; 48?小时) 抑制人结肠癌细胞的生长。Deoxyshikonin (25-100μg/mL；24、48 小时) 诱导早期凋亡细胞死亡。Deoxyshikonin (25-100μg/mL；48 小时) 导致G0/G1期细胞百分比呈剂量依赖性增加。Deoxyshikonin (25-100μg/mL；48 小时) 可降低 HT29 和 DLD-1 细胞系中 PI3K、p-PI3K、Akt、p-Akt308 和 mTOR 蛋白的表达。
Deoxyshikonin increases the expression of VEGF-C and VEGF-A mRNA in HMVEC-dLy, promotes HIF-1α and HIF-1β subunit interaction and binds to specific DNA sequences targeted by HIF. Deoxyshikonin inhibited colorectal cancer (CRC) through the PI3K/Akt/mTOR pathway. Deoxyshikonin has proangiogenesis effect and antitumor activity. Deoxyshikonin is an antibacterial agent against methicillin-resistant S. aureus (MRSA) and S. pneumonia (MIC=17 μg/mL).
体内研究：
Deoxyshikonin (20mg/kg；腹腔注射；每两天一次，持续 13 天) 以 20 mg/kg 剂量在第 5、9 和 11 天，显着抑制异种移植肿瘤的生长。Animal Model:Male BALB/c nude mice of 10-14?g with DLD-1 cells
Dosage:20?mg/kg
Administration:Intraperitoneal injection; every two days for a total of 13 days
Result:Markedly suppressed the growth of xenograft tumours on day 5, 9 and 11 with 20?mg/kg, while there were no significant changes in body weight of the mice.
体外研究：
Deoxyshikonin (6.25-100?μg/mL; 48?小时) 抑制人结肠癌细胞的生长。Deoxyshikonin (25-100μg/mL；24、48 小时) 诱导早期凋亡细胞死亡。Deoxyshikonin (25-100μg/mL；48 小时) 导致G0/G1期细胞百分比呈剂量依赖性增加。Deoxyshikonin (25-100μg/mL；48 小时) 可降低 HT29 和 DLD-1 细胞系中 PI3K、p-PI3K、Akt、p-Akt308 和 mTOR 蛋白的表达。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备