产品
编 号：F355799
分子式：C15H10ClF3N2O3
分子量：358.7
分子式：C15H10ClF3N2O3
分子量：358.7
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 426834-38-0
产品详情
生物活性：
NS3694, a diarylurea compound, is an apoptosome inhibitor. NS3694 inhibits apoptosome formation and caspase activation.
体外研究：
When cell extracts are stimulated with cytochrome c and dATP in the presence of NS3694 (10-100 μM; 120 min), a dose-dependent inhibition of caspase 9, 3, and 7 processing, DFF45/ICAD and PARP cleavage, and DEVDase activity is observed.NS3694 (10-100 μM) inhibits TNF-induced effector caspase activation and apoptosis in MCF-casp3 cells.NS3694 specifically suppresses the cytochrome C-induced formation of apoptosome complex and caspase-9 activation, thus inhibiting the mitochondria-mediated apoptosis. NS3694 inhibits the formation of the apoptosome Apaf-1 by blocking the activation of the initiator caspase-9.
NS3694, a diarylurea compound, is an apoptosome inhibitor. NS3694 inhibits apoptosome formation and caspase activation.
体外研究：
When cell extracts are stimulated with cytochrome c and dATP in the presence of NS3694 (10-100 μM; 120 min), a dose-dependent inhibition of caspase 9, 3, and 7 processing, DFF45/ICAD and PARP cleavage, and DEVDase activity is observed.NS3694 (10-100 μM) inhibits TNF-induced effector caspase activation and apoptosis in MCF-casp3 cells.NS3694 specifically suppresses the cytochrome C-induced formation of apoptosome complex and caspase-9 activation, thus inhibiting the mitochondria-mediated apoptosis. NS3694 inhibits the formation of the apoptosome Apaf-1 by blocking the activation of the initiator caspase-9.
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