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编 号：F355046
分子式：C10H16K2N5O13P3
分子量：585.38
分子式：C10H16K2N5O13P3
分子量：585.38
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CAS No: 42373-41-1
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生物活性：
ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a central component of energy storage and metabolism in vivo. ATP dipotassium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dipotassium is an important endogenous signaling molecule in immunity and inflammation.
体内研究：
ATP dipotassium (50 mg/kg; i.p.) protects mice against bacterial infection in vivo.ATP dipotassium induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo.Animal Model:Four-week-old Kunming mice (18-22 g)
Dosage:50 mg/kg
Administration:Intraperitoneal injection, before bacterial (E. coli) challenge
Result:Protected mice from bacterial infection.
体外研究：
ATP dipotassium (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs.ATP dipotassium (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner.ATP dipotassium promotes neutrophil chemotaxis in vitro.
ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a central component of energy storage and metabolism in vivo. ATP dipotassium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dipotassium is an important endogenous signaling molecule in immunity and inflammation.
体内研究：
ATP dipotassium (50 mg/kg; i.p.) protects mice against bacterial infection in vivo.ATP dipotassium induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo.Animal Model:Four-week-old Kunming mice (18-22 g)
Dosage:50 mg/kg
Administration:Intraperitoneal injection, before bacterial (E. coli) challenge
Result:Protected mice from bacterial infection.
体外研究：
ATP dipotassium (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs.ATP dipotassium (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner.ATP dipotassium promotes neutrophil chemotaxis in vitro.
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