产品
编 号：F354553
分子式：C11H17ClINO2
分子量：357.62
分子式：C11H17ClINO2
分子量：357.62
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 42203-78-1
产品详情
生物活性：
DOI hydrochloride is a serotonin 5-HT2A/2C receptor agonist with Ki values of 0.7 nM, 2.4 nM and 20 nM for h5-HT2A, h5-HT2C and h5-HT2B receptors, respectively. DOI hydrochloride can across the blood-brain barrier. DOI hydrochloride increases head twitches in mice.
体内研究：
DOI hydrochloride (0.3-10 mg/kg; i.p.; single dose) produces an increase in mean head twitches at 3 mg/kg in Wild type (WT) ICR (CD-1) KO mice. Lower doses produces non-significant increases in head twitches, while a higher dose of 10 mg/kg produces increased variability yet a significant increase in mean head twitches.DOI (0.35-0.7 mmol/kg; sc) significantly increases waking and light sleep and reduces slow wave sleep, rapid-eye-movement (REM) sleep, and the number of REM periods in Male Wistar rats weighing 350-400 g.
体外研究：
DOI hydrochloride (10 μM; for 45 min) causes a massive increase in adhesion with 99% of the cells staying adherent compared to only 42% of untreated Hu2AAB1 cells.
DOI hydrochloride is a serotonin 5-HT2A/2C receptor agonist with Ki values of 0.7 nM, 2.4 nM and 20 nM for h5-HT2A, h5-HT2C and h5-HT2B receptors, respectively. DOI hydrochloride can across the blood-brain barrier. DOI hydrochloride increases head twitches in mice.
体内研究：
DOI hydrochloride (0.3-10 mg/kg; i.p.; single dose) produces an increase in mean head twitches at 3 mg/kg in Wild type (WT) ICR (CD-1) KO mice. Lower doses produces non-significant increases in head twitches, while a higher dose of 10 mg/kg produces increased variability yet a significant increase in mean head twitches.DOI (0.35-0.7 mmol/kg; sc) significantly increases waking and light sleep and reduces slow wave sleep, rapid-eye-movement (REM) sleep, and the number of REM periods in Male Wistar rats weighing 350-400 g.
体外研究：
DOI hydrochloride (10 μM; for 45 min) causes a massive increase in adhesion with 99% of the cells staying adherent compared to only 42% of untreated Hu2AAB1 cells.
产品资料
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