产品
编 号：F353394
分子式：C22H30O4
分子量：358.47
分子式：C22H30O4
分子量：358.47
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 41743-44-6
产品详情
生物活性：
Ferutinin, a natural terpenoid compound, is an estrogen receptor ERα agonist and estrogen ERβ-receptor agonist/antagonist with IC50s of 33.1 nM and 180.5 nM, respectively. Ferutinin acts as an electrogenic Ca2+-ionophore that increases calcium permeability of lipid bilayer membranes, mitochondria. Ferutinin possesses estrogenic, antitumor, antibacterial and antiinflammatory activities.
体外研究：
Ferutinin manifested antiproliferative activity, inducing apoptosis in several cell types: MCF-7 estrogen-dependent cancer cells, leukemia T-cell line (Jurkat), human and mouse colon carcinoma cells (Caco-2, CT26, HT29), as well as bladder (TCC) cancer cells. Ferutinin potentiates bone mineralization, and is proposed to be used as an antiosteoporosis phytoestrogen.Ferutinin considerably increases the permeability of artificial and cellular membranes to Ca2+-ions and produces apoptotic cell death in different cell lines in a mitochondria-dependent manner. Ferutinin alone (10-60 μM) also dose-dependently dissipated membrane potential. In the presence of Ca2+-ions, Ferutinin (10-60 μM) induces considerable depolarization of the inner mitochondrial membrane.
Ferutinin, a natural terpenoid compound, is an estrogen receptor ERα agonist and estrogen ERβ-receptor agonist/antagonist with IC50s of 33.1 nM and 180.5 nM, respectively. Ferutinin acts as an electrogenic Ca2+-ionophore that increases calcium permeability of lipid bilayer membranes, mitochondria. Ferutinin possesses estrogenic, antitumor, antibacterial and antiinflammatory activities.
体外研究：
Ferutinin manifested antiproliferative activity, inducing apoptosis in several cell types: MCF-7 estrogen-dependent cancer cells, leukemia T-cell line (Jurkat), human and mouse colon carcinoma cells (Caco-2, CT26, HT29), as well as bladder (TCC) cancer cells. Ferutinin potentiates bone mineralization, and is proposed to be used as an antiosteoporosis phytoestrogen.Ferutinin considerably increases the permeability of artificial and cellular membranes to Ca2+-ions and produces apoptotic cell death in different cell lines in a mitochondria-dependent manner. Ferutinin alone (10-60 μM) also dose-dependently dissipated membrane potential. In the presence of Ca2+-ions, Ferutinin (10-60 μM) induces considerable depolarization of the inner mitochondrial membrane.
产品资料
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