产品
编 号：F353125
分子式：C23H34O5
分子量：390.51
分子式：C23H34O5
分子量：390.51
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 41639-83-2
产品详情
生物活性：
Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor. Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes.
体内研究：
Latanoprost acid (i.p.; 20 mg/kg; once a day for 7 days) notably prevents LPS-induced bone destruction at a dose of 20mg/kg. Animal Model:8-week-old C57BL/6J mice
Dosage:20 mg/kg
Administration:Intraperitoneally injected; once a day for 7 days
Result:Notably prevented LPS-induced bone destruction at a dose of 20mg/kg.
体外研究：
Latanoprost acid (10-20 μM;24 hours) reduces he protein expressions of c-fos and NFATc1. Latanoprost acid (10μM with 50ng/ml RANKL) significantly inhibits ERK, p38, AKT and JNK. Latanoprost acid (10 μM, 20 μM) significantly inhibits the mature osteoclast formation.
Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor. Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes.
体内研究：
Latanoprost acid (i.p.; 20 mg/kg; once a day for 7 days) notably prevents LPS-induced bone destruction at a dose of 20mg/kg. Animal Model:8-week-old C57BL/6J mice
Dosage:20 mg/kg
Administration:Intraperitoneally injected; once a day for 7 days
Result:Notably prevented LPS-induced bone destruction at a dose of 20mg/kg.
体外研究：
Latanoprost acid (10-20 μM;24 hours) reduces he protein expressions of c-fos and NFATc1. Latanoprost acid (10μM with 50ng/ml RANKL) significantly inhibits ERK, p38, AKT and JNK. Latanoprost acid (10 μM, 20 μM) significantly inhibits the mature osteoclast formation.
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