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编 号：F040251
分子式：C19H20ClNO
分子量：313.82
分子式：C19H20ClNO
分子量：313.82
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CAS No: 112108-01-7
产品详情
生物活性：
Ecopipam (SCH 39166) is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam can be used for the research of schizophrenia and obesity.
体内研究：
Ecopipam (0.003-0.3 mg/kg；单次；皮下注射) 消除成年大鼠尼古丁诱导的感觉增强剂增强作用。Ecopipam (10 mg/kg，口服) 拮抗大鼠中 Apomorphine 诱导的刻板印象。Ecopipam (5 和 10 μM，灌注，1 μL/分钟) 可逆地和剂量依赖性地减少大鼠纹状体中乙酰胆碱的释放。Animal Model:Male young adult Long-Evans rats injected with Nicotine
Dosage:0.003, 0.01, 0.03, 0.1, 0.3 mg/kg
Administration:A single s.c. 20 min before Nicotine (0.1 mg/kg)
Result:Dose-dependently reduced pressing on both active and inactive levers.
体外研究：
Ecopipam (2 μM) 完全消除多巴胺 (10 μM) 在离体皮质海马结构中的促惊厥作用。
Ecopipam (SCH 39166) is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam can be used for the research of schizophrenia and obesity.
体内研究：
Ecopipam (0.003-0.3 mg/kg；单次；皮下注射) 消除成年大鼠尼古丁诱导的感觉增强剂增强作用。Ecopipam (10 mg/kg，口服) 拮抗大鼠中 Apomorphine 诱导的刻板印象。Ecopipam (5 和 10 μM，灌注，1 μL/分钟) 可逆地和剂量依赖性地减少大鼠纹状体中乙酰胆碱的释放。Animal Model:Male young adult Long-Evans rats injected with Nicotine
Dosage:0.003, 0.01, 0.03, 0.1, 0.3 mg/kg
Administration:A single s.c. 20 min before Nicotine (0.1 mg/kg)
Result:Dose-dependently reduced pressing on both active and inactive levers.
体外研究：
Ecopipam (2 μM) 完全消除多巴胺 (10 μM) 在离体皮质海马结构中的促惊厥作用。
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