产品
编 号:F352343
分子式:C27H44O2
分子量:400.64
产品类型
结构图
CAS No: 41294-56-8
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生物活性:
Alfacalcidol (1-hydroxycholecalciferol) is a vitamin D active metabolites, acts as a non-selective VDR activator medication, and widely be used in the management of osteoporosis.
体内研究:
Alfacalcidol (0.025-0.1 mg/kg;口服;每周 5 次;持续 3 个月) 独立于钙相关作用发挥骨保护作用,在这方面优于维生素 D (3),并且骨骼 Alfacalcidol 的作用至少部分独立于 PTH 的抑制。Animal Model:Female Wistar-Imamichi rats (8 months old), ovariectomized
Dosage:0.025 mg/kg, 0.05 mg/kg, 0.1 mg/kg
Administration:Oral administration; five times a week; for 3 months
Result:Exerted bone-protective effects independently of its Ca-related effects