产品
编 号：F350880
分子式：C18H21NO4S
分子量：347.43
分子式：C18H21NO4S
分子量：347.43
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 407587-33-1
产品详情
生物活性：
CaCCinh-A01 is an inhibitor of both TMEM16A and calcium-activated chloride channel (CaCC) with IC50s of 2.1 and 10 μM, respectively.
体内研究：
CaCCinh-A01 (vein injection; 5 mg/kg; caudal vein injection within 15 min after the onset of reperfusion) significantly reduces infarction when compared with MCAO-saline treatment at 24 h or 72 h in middle cerebral artery occlusion model in mice.Animal Model:Two-month-old male C57/BL6J mice
Dosage:5 mg/kg
Administration:Vein injection; 5 mg/kg; caudal vein injection within 15 min after the onset of reperfusion
Result:Attenuated brain infarct size, improved neurological outcomes and lowered BBB permeability after ischemic stroke in mice.
体外研究：
30 μM CaCCinh-A01 and 100 μM tannic acid strongly inhibit CaCC current following ATP stimulation. Calcium-dependent chloride current is reduced by 38±14, 66±10, and 91±1% by 0.1, 1, and 10 μM CaCCinh-A01, respectively. ATP-induced short-circuit currents are reduced by 38±7 and 78±3% at 10 and 30 μM CaCCinh-A01, respectively.
CaCCinh-A01 is an inhibitor of both TMEM16A and calcium-activated chloride channel (CaCC) with IC50s of 2.1 and 10 μM, respectively.
体内研究：
CaCCinh-A01 (vein injection; 5 mg/kg; caudal vein injection within 15 min after the onset of reperfusion) significantly reduces infarction when compared with MCAO-saline treatment at 24 h or 72 h in middle cerebral artery occlusion model in mice.Animal Model:Two-month-old male C57/BL6J mice
Dosage:5 mg/kg
Administration:Vein injection; 5 mg/kg; caudal vein injection within 15 min after the onset of reperfusion
Result:Attenuated brain infarct size, improved neurological outcomes and lowered BBB permeability after ischemic stroke in mice.
体外研究：
30 μM CaCCinh-A01 and 100 μM tannic acid strongly inhibit CaCC current following ATP stimulation. Calcium-dependent chloride current is reduced by 38±14, 66±10, and 91±1% by 0.1, 1, and 10 μM CaCCinh-A01, respectively. ATP-induced short-circuit currents are reduced by 38±7 and 78±3% at 10 and 30 μM CaCCinh-A01, respectively.
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