产品
编 号：F040008
分子式：C21H25N3O2S
分子量：383.51
分子式：C21H25N3O2S
分子量：383.51
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 111974-69-7
产品详情
生物活性：
Quetiapine (ICI204636) is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects.
体内研究：
Quetiapine (10 mg/kg/天；摄入) 可以减轻铜宗 (CPZ) 诱导的慢性脱髓鞘小鼠模型中小胶质细胞的募集和激活，促进髓鞘修复。Animal Model:C57BL/6 mice
Dosage:10?mg/kg/day
Administration:Ingested
Result:Significantly increased in optical density of myelin basic protein (MBP) staining compared to Veh group.
体外研究：
Quetiapine (Quetiapine 相关抗体:Cell Viability AssayCell Line:N9 microglial cells
Concentration:0, 0.1, 1, 10, 50, and 100?μM
Incubation Time:24?hours
Result:Had no significant effect on cell viabilities at various concentrations under 100?μM, in which significant toxicity could be observed.
RT-PCRCell Line:N9 microglial cells
Concentration:10?μM
Incubation Time:24?hours
Result:Dramatically inhibited TNF-α synthesis.
Quetiapine (ICI204636) is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects.
体内研究：
Quetiapine (10 mg/kg/天；摄入) 可以减轻铜宗 (CPZ) 诱导的慢性脱髓鞘小鼠模型中小胶质细胞的募集和激活，促进髓鞘修复。Animal Model:C57BL/6 mice
Dosage:10?mg/kg/day
Administration:Ingested
Result:Significantly increased in optical density of myelin basic protein (MBP) staining compared to Veh group.
体外研究：
Quetiapine (Quetiapine 相关抗体:Cell Viability AssayCell Line:N9 microglial cells
Concentration:0, 0.1, 1, 10, 50, and 100?μM
Incubation Time:24?hours
Result:Had no significant effect on cell viabilities at various concentrations under 100?μM, in which significant toxicity could be observed.
RT-PCRCell Line:N9 microglial cells
Concentration:10?μM
Incubation Time:24?hours
Result:Dramatically inhibited TNF-α synthesis.
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