产品
编 号:F349278
分子式:C19H38N2O
分子量:310.52
产品类型
结构图
CAS No: 402939-18-8
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产品详情
生物活性:
1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) increases epoxyeicosatrienoic acids (EETs) levels and lowers blood pressure in angiotensin II (Ang II) hypertension.
体内研究:
1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) (?intraperitoneal injection; 3mg/day; 4 days) lowers systolic blood pressure by 30 mm Hg in Ang II hypertensive animals, whereas the corn oil vehicle has no effect on blood pressure in normotensive or Ang II hypertensive animals.Animal Model:Male Sprague-Dawley rats
Dosage:3mg/day
Administration:Intraperitoneal injection; 4 days
Result:Had antihypertensive properties.