产品
编 号:F349100
分子式:C19H34NO5P
分子量:387.45
产品类型
结构图
CAS No: 402615-91-2
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产品详情
生物活性:
Fingolimod phosphate (FTY720 phosphate) is an orally active sphingosine 1-phosphate (S1P) receptor agonist. Fingolimod phosphate can promote the neuroprotective effects of microglia. Fingolimod phosphate can be used for the research of multiple sclerosis and neurologic diseases.
体外研究:
Fingolimod phosphate prevents lymphocytes from moving out of the lymphoid organs and inhibits autoreactive lymphocytes from infiltrating the central nervous system. Fingolimod phosphate (0, 1, 10, 100 nM) binds S1P1 receptors to downregulate activated microglial production of such pro-inflammatory cytokines as tumor necrosis factor-a, interleukin-1β, and interleukin-6.Fingolimod phosphate (0, 1, 10, 100 nM) also upregulates microglial production of brain-derived neurotrophic factor and glial cell-derived neurotrophic factor.