产品
编 号：F039750
分子式：C23H28N2O5S2
分子量：476.61
分子式：C23H28N2O5S2
分子量：476.61
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 111902-57-9
产品详情
生物活性：
Temocapril is an orally active angiotensin-converting enzyme (ACE) inhibitor. Temocapril can be used for the research of hypertension, congestive heart failure, acute myocardial infarction, insulin resistance, and renal diseases.
体内研究：
Temocapril (10 mg/kg; p.o.; 21 d) enhances cardiomyocyte thioredoxin expression and ameliorates autoimmune myocarditis.Temocapril (30 mg/kg; p.o.; daily; for 4 weeks) suppresses Angiotensin I-induced hypertension, plasma and renal ACE activity, but fails to reduce the level of Ang II in the kidney.Animal Model:Experimental autoimmune myocarditis (EAM) rat model
Dosage:10 mg/kg
Administration:Oral gavage; administration by water; 21 days
Result:Ameliorated EAM and prevented cellular proteins from oxidation.Enhanced cardiomyocyte redox regulatory protein TRX expression.
Animal Model:Male Sprague Dawley rats
Dosage:30 mg/kg
Administration:Oral gavage, daily, for 4 weeks
Result:Suppressed the blood pressure elevation induced by Ang I.
体外研究：
Temocapril hydrochloride is a prodrug of the ACE inhibitor, Temocaprilat. Temocapril hydrochloride can be readily uptaken via the small intestine, and then be converted to its active metabolite (temocaprilat) by CES1 (human carboxylesterase 1) in the liver.Temocapril hydrochloride (500 nM) reduces the inhibitory effects of RS (N-acetyltetradecapeptide renin substrate) and AngI (angiotensin) on neurogenic vasodilation in the spontaneously hypertensive rats (SHR).Temocapril hydrochloride (0.1-10 μM; 24 h) shows inductive effects on redox proteins thioredoxin (TRX) while no effect on antioxidant enzymes Cu/ZnSOD and Mn-SOD expressions.
Temocapril is an orally active angiotensin-converting enzyme (ACE) inhibitor. Temocapril can be used for the research of hypertension, congestive heart failure, acute myocardial infarction, insulin resistance, and renal diseases.
体内研究：
Temocapril (10 mg/kg; p.o.; 21 d) enhances cardiomyocyte thioredoxin expression and ameliorates autoimmune myocarditis.Temocapril (30 mg/kg; p.o.; daily; for 4 weeks) suppresses Angiotensin I-induced hypertension, plasma and renal ACE activity, but fails to reduce the level of Ang II in the kidney.Animal Model:Experimental autoimmune myocarditis (EAM) rat model
Dosage:10 mg/kg
Administration:Oral gavage; administration by water; 21 days
Result:Ameliorated EAM and prevented cellular proteins from oxidation.Enhanced cardiomyocyte redox regulatory protein TRX expression.
Animal Model:Male Sprague Dawley rats
Dosage:30 mg/kg
Administration:Oral gavage, daily, for 4 weeks
Result:Suppressed the blood pressure elevation induced by Ang I.
体外研究：
Temocapril hydrochloride is a prodrug of the ACE inhibitor, Temocaprilat. Temocapril hydrochloride can be readily uptaken via the small intestine, and then be converted to its active metabolite (temocaprilat) by CES1 (human carboxylesterase 1) in the liver.Temocapril hydrochloride (500 nM) reduces the inhibitory effects of RS (N-acetyltetradecapeptide renin substrate) and AngI (angiotensin) on neurogenic vasodilation in the spontaneously hypertensive rats (SHR).Temocapril hydrochloride (0.1-10 μM; 24 h) shows inductive effects on redox proteins thioredoxin (TRX) while no effect on antioxidant enzymes Cu/ZnSOD and Mn-SOD expressions.
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