产品
编 号：F346669
分子式：C21H23NO3S
分子量：369.48
分子式：C21H23NO3S
分子量：369.48
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 395683-14-4
产品详情
生物活性：
Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor with an IC50 value of 18 nM, it also inhibits COX1- activity with an IC50 value of 115 nM. Imrecoxib (BAP-909) has anti-inflammatory effect.
体内研究：
Imrecoxib (BAP-909) (gastrointestinal administration; 5-20 mg/kg; 1 hour before carrageenan injection) inhibits carrageenan-induced acute inflammation, and the inhibitory effect is maximal at 4 hours.Imrecoxib (BAP-909) (gastrointestinal administration; 5-20 mg/kg; started on day 7; 26 days) diminishes the secondary paw swelling and inhibits heat-inactivated BCG induced-inflammtory polyarthritis.Animal Model:Rat carrageenan-induced edema model
Dosage:5 mg/kg, 10 mg/kg, 20 mg/kg
Administration:Gastrointestinal administration; 5-20 mg/kg; 1 hour before carrageenan injection
Result:Inhibited the edema response with different doses.
Animal Model:Rat adjuvant-induced arthritis (AIA) model
Dosage:5 mg/kg, 10 mg/kg, 20 mg/kg
Administration:Gastrointestinal administration; 5-20 mg/kg; started on day 7; 26 days
Result:Inhibited adjuvant-induced chronic inflammation at the doses of 10 and 20 mg/kg.
体外研究：
Imrecoxib (BAP-909) (0.1-10 μM; 24 hours) decreases COX-2 mRNA level induced by PMA+LPS at a dose dependent manner in U937 cells.
Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 (COX-2) inhibitor with an IC50 value of 18 nM, it also inhibits COX1- activity with an IC50 value of 115 nM. Imrecoxib (BAP-909) has anti-inflammatory effect.
体内研究：
Imrecoxib (BAP-909) (gastrointestinal administration; 5-20 mg/kg; 1 hour before carrageenan injection) inhibits carrageenan-induced acute inflammation, and the inhibitory effect is maximal at 4 hours.Imrecoxib (BAP-909) (gastrointestinal administration; 5-20 mg/kg; started on day 7; 26 days) diminishes the secondary paw swelling and inhibits heat-inactivated BCG induced-inflammtory polyarthritis.Animal Model:Rat carrageenan-induced edema model
Dosage:5 mg/kg, 10 mg/kg, 20 mg/kg
Administration:Gastrointestinal administration; 5-20 mg/kg; 1 hour before carrageenan injection
Result:Inhibited the edema response with different doses.
Animal Model:Rat adjuvant-induced arthritis (AIA) model
Dosage:5 mg/kg, 10 mg/kg, 20 mg/kg
Administration:Gastrointestinal administration; 5-20 mg/kg; started on day 7; 26 days
Result:Inhibited adjuvant-induced chronic inflammation at the doses of 10 and 20 mg/kg.
体外研究：
Imrecoxib (BAP-909) (0.1-10 μM; 24 hours) decreases COX-2 mRNA level induced by PMA+LPS at a dose dependent manner in U937 cells.
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