产品
编 号：F039651
分子式：C63H73N11O9S2
分子量：1192.45
分子式：C63H73N11O9S2
分子量：1192.45
产品类型
规格
价格
是否有货
结构图
CAS No: 111857-96-6
产品详情
生物活性：
BIM 23042, a certain somatostatin (SS) octapeptide analogue, is a selective neuropeptide neuromedin B receptor (NMB-R, BB1) antagonist. BIM 23042 has 100-fold lower affinity for gastrin-releasing peptide (GRP) receptor (BB2). BIM 23042 inhibits Neuromedin?B?(HY-P0241), ICI 216140 and DPDM-bombesin ethylamide-induced Ca2+ release.
体内研究：
BIM 23042 (10μg; 静脉给药; 单次推注) 可减轻神经源性肿胀和热和机械致敏。Animal Model:Mice were 25-30 g male C57BL/6
Dosage:10 μg
Administration:IV; a single bolus
Result:Attenuatedneurogenic swelling and thermal and mechanical sensitization.
体外研究：
BIM 23042 (5 μM) 在 huNMBR 细胞中竞争性抑制 Neuromedin B 诱导的 [3H] 花生四烯酸释放，Ki 为 49 nM。
BIM 23042, a certain somatostatin (SS) octapeptide analogue, is a selective neuropeptide neuromedin B receptor (NMB-R, BB1) antagonist. BIM 23042 has 100-fold lower affinity for gastrin-releasing peptide (GRP) receptor (BB2). BIM 23042 inhibits Neuromedin?B?(HY-P0241), ICI 216140 and DPDM-bombesin ethylamide-induced Ca2+ release.
体内研究：
BIM 23042 (10μg; 静脉给药; 单次推注) 可减轻神经源性肿胀和热和机械致敏。Animal Model:Mice were 25-30 g male C57BL/6
Dosage:10 μg
Administration:IV; a single bolus
Result:Attenuatedneurogenic swelling and thermal and mechanical sensitization.
体外研究：
BIM 23042 (5 μM) 在 huNMBR 细胞中竞争性抑制 Neuromedin B 诱导的 [3H] 花生四烯酸释放，Ki 为 49 nM。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备