产品
编 号：F346024
分子式：C30H31NO10
分子量：565.57
分子式：C30H31NO10
分子量：565.57
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CAS No: 39277-41-3
产品详情
生物活性：
Viridicatumtoxin is a new mycotoxin extracted from Penicillium viridicatum with a LD50 of 122.4 mg/kg in rats.
体内研究：
Viridicatumtoxin (60-400 mg/kg; i.p., p.o., s.c; ICR mice, Sprague-Dawley rats and mature Wistar rats (4/5 weeks; 16-20 g/140-150 g)) has no signs of toxicity with p.o. administration. As the dosage increasing (i.p. and p.o.), hepatocytes starts to have pathological changes and deaths occurrs in both mice and rats. Mice and rats which given the viridicatumtoxin by s.c. has no signs of toxicity and none die, but coagulation necrosis is present at the injection site.Animal Model:ICR mice, Sprague-Dawley rats and mature Wistar rats (4/5 weeks; 16-20 g/140-150 g)
Dosage:60-400 mg/kg
Administration:i.p., p.o., s.c.
Result:Orally with viridicatumtoxin had no signs of toxicity. As the dosage increasing (i.p. and p.o.), hepatocytes started to have pathological changes and deaths occurred in both mice and rats. Mice and rats which given the viridicatumtoxin by s.c. had no signs of toxicity and none died, but coagulation necrosis was present at the injection site.
Viridicatumtoxin is a new mycotoxin extracted from Penicillium viridicatum with a LD50 of 122.4 mg/kg in rats.
体内研究：
Viridicatumtoxin (60-400 mg/kg; i.p., p.o., s.c; ICR mice, Sprague-Dawley rats and mature Wistar rats (4/5 weeks; 16-20 g/140-150 g)) has no signs of toxicity with p.o. administration. As the dosage increasing (i.p. and p.o.), hepatocytes starts to have pathological changes and deaths occurrs in both mice and rats. Mice and rats which given the viridicatumtoxin by s.c. has no signs of toxicity and none die, but coagulation necrosis is present at the injection site.Animal Model:ICR mice, Sprague-Dawley rats and mature Wistar rats (4/5 weeks; 16-20 g/140-150 g)
Dosage:60-400 mg/kg
Administration:i.p., p.o., s.c.
Result:Orally with viridicatumtoxin had no signs of toxicity. As the dosage increasing (i.p. and p.o.), hepatocytes started to have pathological changes and deaths occurred in both mice and rats. Mice and rats which given the viridicatumtoxin by s.c. had no signs of toxicity and none died, but coagulation necrosis was present at the injection site.
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