产品
编 号：F345425
分子式：C30H46O4
分子量：470.68
分子式：C30H46O4
分子量：470.68
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 39111-07-4
产品详情
生物活性：
Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model.
体内研究：
Nigranoic acid has a strong protective effect on rat cerebral ischemia-reperfusion injury, and acts by downregulating nerve cell apoptosis by preventing the overactivation of PARP and AIF nuclear translocation. Nigranoic acid (1 mg/kg; i.g.; 6 hours and 2 hours before brain ischemia) significantly decreases apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points.Animal Model:Sprague–Dawley rats (200-300 g), ischemia–reperfusion model
Dosage:1 mg/kg
Administration:Intragastric; 6 hours and 2 hours before brain ischemia
Result:Decreased apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points.
Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model.
体内研究：
Nigranoic acid has a strong protective effect on rat cerebral ischemia-reperfusion injury, and acts by downregulating nerve cell apoptosis by preventing the overactivation of PARP and AIF nuclear translocation. Nigranoic acid (1 mg/kg; i.g.; 6 hours and 2 hours before brain ischemia) significantly decreases apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points.Animal Model:Sprague–Dawley rats (200-300 g), ischemia–reperfusion model
Dosage:1 mg/kg
Administration:Intragastric; 6 hours and 2 hours before brain ischemia
Result:Decreased apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points.
产品资料
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