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编 号：F039446
分子式：C17H21ClN2O
分子量：304.81
分子式：C17H21ClN2O
分子量：304.81
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CAS No: 111686-79-4
产品详情
生物活性：
Remacemide hydrochloride (FPL 12924AA), a moderate inhibitor of the Na+ channel, is a weak uncompetitive NMDA receptor antagonist with IC50s of 68 μM and 76 μM for MK-801 binding and NMDA currents, respectively. Remacemide hydrochloride is an anticonvulsant agent.
体内研究：
Treatment with low- and high-dose Remacemide (100 mg/kg and 150 mg/kg) delays the acquisition of audio/visual discrimination (AVD) task performance in female Sprague-Dawley rats.Animal Model:Female Sprague–Dawley rats ( 190-210 g )
Dosage:100 mg/kg and 150 mg/kg
Administration:Orogastric gavage; once a day; 7 days
Result:Increased the number of sessions required to complete audio/visual discrimination (AVD) training.
体外研究：
Remacemide (hydrochloride) (0-1000 μM) blocks voltage-gated Na+ channels in rat cortical synaptosomes in a concentration-dependent manner,with an IC50 value of 160.6 μM.
Remacemide hydrochloride (FPL 12924AA), a moderate inhibitor of the Na+ channel, is a weak uncompetitive NMDA receptor antagonist with IC50s of 68 μM and 76 μM for MK-801 binding and NMDA currents, respectively. Remacemide hydrochloride is an anticonvulsant agent.
体内研究：
Treatment with low- and high-dose Remacemide (100 mg/kg and 150 mg/kg) delays the acquisition of audio/visual discrimination (AVD) task performance in female Sprague-Dawley rats.Animal Model:Female Sprague–Dawley rats ( 190-210 g )
Dosage:100 mg/kg and 150 mg/kg
Administration:Orogastric gavage; once a day; 7 days
Result:Increased the number of sessions required to complete audio/visual discrimination (AVD) training.
体外研究：
Remacemide (hydrochloride) (0-1000 μM) blocks voltage-gated Na+ channels in rat cortical synaptosomes in a concentration-dependent manner,with an IC50 value of 160.6 μM.
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