产品
编 号：F344196
分子式：C20H22O6
分子量：358.39
分子式：C20H22O6
分子量：358.39
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 38647-11-9
产品详情
生物活性：
Triptonide (NSC 165677) is a natural product identified in Tripterygium wilfordii Hook F.. Triptonide is a Wnt signaling inhibitor with an IC50 of appropriately 0.3?nM. Triptonide has immunosuppression, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects.
体内研究：
Triptonide (5 mg/kg; i.p.; daily; for 34 days) exerts a strong anti-lymphoma effect in mice.Animal Model:Eight-week-old female NOD/SCID mice (18-22 g), with 3 x 107 Raji cells xenograft
Dosage:5 mg/kg
Administration:Intraperitoneal injection, daily, for 34 days
Result:Potently inhibited lymphoma cell growth and tumorigenic capability.
体外研究：
Triptonide blocks Wnt/β-catenin signaling via C-terminal transactivation domain of β-catenin, and promots apoptosis in Wnt-dependent cancer cells.Triptonide potently inhibits the proliferation of human B-lymphoma Raji and T-lymphoma Jurkat cells with IC50 of 5.7 nM and 4.8 nM, respectively.Triptonide (2.5-10 nM; 6 days) significantly suppresses B-lymphoma cell colony-forming capability.Triptonide (20 nM; 3 days) promotes apoptosis through activation of PARP and caspase 3, but reduction of BCL2 protein levels in the lymphoma cells.Triptonide (5-10 nM; 72 hours) markedly reduces both total and phosphorylated Lyn proteins, and diminishes Lyn downstream ERK and ATK signal pathways.
Triptonide (NSC 165677) is a natural product identified in Tripterygium wilfordii Hook F.. Triptonide is a Wnt signaling inhibitor with an IC50 of appropriately 0.3?nM. Triptonide has immunosuppression, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects.
体内研究：
Triptonide (5 mg/kg; i.p.; daily; for 34 days) exerts a strong anti-lymphoma effect in mice.Animal Model:Eight-week-old female NOD/SCID mice (18-22 g), with 3 x 107 Raji cells xenograft
Dosage:5 mg/kg
Administration:Intraperitoneal injection, daily, for 34 days
Result:Potently inhibited lymphoma cell growth and tumorigenic capability.
体外研究：
Triptonide blocks Wnt/β-catenin signaling via C-terminal transactivation domain of β-catenin, and promots apoptosis in Wnt-dependent cancer cells.Triptonide potently inhibits the proliferation of human B-lymphoma Raji and T-lymphoma Jurkat cells with IC50 of 5.7 nM and 4.8 nM, respectively.Triptonide (2.5-10 nM; 6 days) significantly suppresses B-lymphoma cell colony-forming capability.Triptonide (20 nM; 3 days) promotes apoptosis through activation of PARP and caspase 3, but reduction of BCL2 protein levels in the lymphoma cells.Triptonide (5-10 nM; 72 hours) markedly reduces both total and phosphorylated Lyn proteins, and diminishes Lyn downstream ERK and ATK signal pathways.
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