产品
编 号:F343512
分子式:C15H16ClN3O3
分子量:321.76
产品类型
结构图
CAS No: 383907-47-9
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产品详情
生物活性:
DA 3003-2 is a potent and selectively Cdc25 inhibitor. DA 3003-2 shows antiproliferative activity. DA 3003-2 induces cell cycle arrest at the G2/M phase and increases the expression of P-tyr15 Cdc2. DA 3003-2 has the potential for the research of prostate cancer.
体外研究:
DA 3003-2 (0.3-30 μM; 48 h) 在 PC-3 细胞中显示出抗增殖活性,IC50 值为 5 μM。DA 3003-2 (5, 10 μM; 24, 1 h) 诱导细胞周期停滞在 G2/M 期并增加 PC-3 细胞中 P-tyr15 Cdc2 的表达[ 1]。