产品
编 号:F342851
分子式:C6H5ClN2O4S
分子量:236.63
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10mM*1mL in DMSO
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5mg
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10mg
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25mg
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50mg
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100mg
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生物活性:
PK11000 is an alkylating agent, and stabilizes the DNA-binding domain of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding. PK11000 has anti-tumor activities.

体外研究:
PK11000 (0-120 μM, 24 h) mildly inhibits mutant p53 cancer cells.PK11000 (0-50 μM, 5 d) shows anti-proliferation effects of breast cell lines.
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