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编 号：F342731
分子式：C15H22O2
分子量：234.33
分子式：C15H22O2
分子量：234.33
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CAS No: 38230-32-9
产品详情
生物活性：
Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity.
体内研究：
Dehydrocurdione (P.o ;120 mg/kg, daily for 12 days) significantly reduces chronic adjuvant arthritis.Dehydrocurdione (200 mg/kg; p.o.; Sprague-Dawley rats) dose-dependently inhibits carrageenan-induced paw edema.Animal Model:Wistar rats
Dosage:120 mg/kg
Administration:P.o ; daily for 12 days
Result:Significantly reduces chronic adjuvant arthritis.
体外研究：
Dehydrocurdione (RAW 264.7 cells) concentration-dependently increases the HO-1 mRNA level for 3 hr and the protein level for 6 hr, and both effects reached significance at a concentration of 100 μM.Dehydrocurdione interacts with Keap, resulting in Nrf2 translocation followed by activation ofthe HO-1 E2 enhancer.
Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity.
体内研究：
Dehydrocurdione (P.o ;120 mg/kg, daily for 12 days) significantly reduces chronic adjuvant arthritis.Dehydrocurdione (200 mg/kg; p.o.; Sprague-Dawley rats) dose-dependently inhibits carrageenan-induced paw edema.Animal Model:Wistar rats
Dosage:120 mg/kg
Administration:P.o ; daily for 12 days
Result:Significantly reduces chronic adjuvant arthritis.
体外研究：
Dehydrocurdione (RAW 264.7 cells) concentration-dependently increases the HO-1 mRNA level for 3 hr and the protein level for 6 hr, and both effects reached significance at a concentration of 100 μM.Dehydrocurdione interacts with Keap, resulting in Nrf2 translocation followed by activation ofthe HO-1 E2 enhancer.
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