产品
编 号:F039263
分子式:C6H14ClNO2S
分子量:199.7
产品类型
结构图
CAS No: 1115-84-0
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产品详情
生物活性:
Vitamin U (S-Methylmethionine sulfonium) chloride is an orally active anti-ulcer agent with antioxidant activity. Vitamin U inhibits adipocyte differentiation. Vitamin U promotes skin wound healing.Vitamin U can be used in the research of gastrointestinal ulceration.
体内研究:
Vitamin U chloride (50 mg/kg, oral gavage) prevents valproic acid-induced liver injury in rats.Vitamin U chloride (50 mg/kg, oral gavage for 3 days) shows antioxidant effect and prevents GalN-induced gastric damage in rats.Animal Model:Valproic acid (VPA)-induced rats with liver damage
Dosage:50 mg/kg
Administration:Oral gavage
Result:Blocked the decrease in catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx), and superoxide dismutase (SOD) activities.Increased in the levels of IL-1β, active caspase-3, and cytoplasmic cytochrome c. Increased in the number of proliferating cells nuclear antigen (PCNA) positive hepatocytes.
体外研究:
Vitamin U chloride (100 μM, 24 h) promotes the growth and migration of human dermal fibroblasts(hDFs).Vitamin U chloride (0-1 mM, 24 h) activates ERK1/2 in hDFs.Vitamin U chloride (0.1 g/L in the nutrient solution) reduces cell membrane damage in higher plants exposed to low-temperature stress.Vitamin U chloride (10-100 mM, 7 days) inhibits adipocyte differentiation via down-regulation of adipogenic factors and up-regulation of AMPK activity.