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编 号:F039199
分子式:C15H16ClN7O3.xHCl
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生物活性:
UCD38B hydrochloride is a cell permeant, competitive enzymatic uPA inhibitor with an IC50 value of 7 μM. UCD38B hydrochloride targets intracellular uPA causing mistrafficking of uPA into perinuclear mitochondria, reducing the mitochondrial membrane potential, and followed by the release of apoptotic inducible factor (AIF). UCD38B hydrochloride induces apoptosis.

体外研究:
UCD38B hydrochloride (10-250 μM; 1h) has cell permeant in U87MG cells.UCD38B hydrochloride (10-250 μM; 1h) inhibits cell growth with an IC50 value of 100 μM.
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