产品
编 号：F339710
分子式：C23H31N3O3
分子量：397.51
分子式：C23H31N3O3
分子量：397.51
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 372523-75-6
产品详情
生物活性：
TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1.
体内研究：
TCS-OX2-29 (5-10 mg/kg; intraperitoneal injection; adult male NMRI mice) treatment suppresses conditioned place preference (CPP) acquisition and expression in both na?ve and dependent mice significantly.Animal Model:440 adult male NMRI mice (25-30 g)
Dosage:5 mg/kg and 10 mg/kg
Administration:Intraperitoneal injection (Pharmacokinetic study)
Result:Suppressed conditioned place preference (CPP) acquisition and expression in both na?ve and dependent mice significantly.
体外研究：
TCS-OX2-29 inhibits orexin A induced IP3 accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX2 receptor.
TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1.
体内研究：
TCS-OX2-29 (5-10 mg/kg; intraperitoneal injection; adult male NMRI mice) treatment suppresses conditioned place preference (CPP) acquisition and expression in both na?ve and dependent mice significantly.Animal Model:440 adult male NMRI mice (25-30 g)
Dosage:5 mg/kg and 10 mg/kg
Administration:Intraperitoneal injection (Pharmacokinetic study)
Result:Suppressed conditioned place preference (CPP) acquisition and expression in both na?ve and dependent mice significantly.
体外研究：
TCS-OX2-29 inhibits orexin A induced IP3 accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX2 receptor.
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