产品
编 号:F339687
分子式:C20H35NO13
分子量:497.49
产品类型
结构图
CAS No: 37248-47-8
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生物活性:
Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1?μg/mL. Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC50 of 72 μM. Validamycin A is a reversible tyrosinase inhibitor, with a Ki of 5.893 mM.
体外研究:
Validamycin A (0.5-1 μg/mL;18 小时) 抑制 A.flavus 的生长和分生孢子萌发延迟。 Validamycin A 对人支气管上皮细胞无细胞毒性。 Validamycin A 直接结合酪氨酸酶活性位点的几个残基,包括 HIS85、HIS244、GLU256、HIS259 和 ASN260。