产品
编 号:F339081
分子式:C14H22N4O2
分子量:278.35
产品类型
结构图
CAS No: 370-81-0
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产品详情
生物活性:
Cuprizone is a copper chelating agent that forms a deep blue copper ketone complex with copper (II). The copper ketone reaction can be used in colorimetric tests for the presence of trace copper. Cuprizone can be used to induce some schizophrenia-like behavior in mice. Cuprizone acts on copper enzymes, including SOD1, cytochrome oxidase, and DβH, thereby causing oxidative stress and increasing DA levels in certain brain regions such as the medial prefrontal cortex (PFC).
体内研究:
Cuprizone (加入饲料或饮用水喂食,0.5 mg/100 mg;口服) 在中枢神经系统产生严重的海绵状状态,最明显的是在小鼠的脑干和小脑白质中。