产品
编 号：F039011
分子式：C29H28ClF3N6O
分子量：569.02
分子式：C29H28ClF3N6O
分子量：569.02
产品类型
规格
价格
是否有货
1mg
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 1114544-31-8
产品详情
生物活性：
Ponatinib hydrochloride (AP24534 hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.
体内研究：
Ponatinib hydrochloride (溶解于 25 mM 柠檬酸缓冲液 (pH 2.75) 中，体积 200 μL, 口服) 通过抑制细胞因子风暴保护小鼠免受致命流感感染。Animal Model:Influenza A Virus Infected Mice
Dosage:200 μL, dissolved in 25 mM citrate buffer (pH 2.75)
Administration:p.o.
Result:Had higher survival rates and reduced the infiltration of neutrophils.
体外研究：
Ponatinib hydrochloride (0.11, 017 μM, 24-48 h) 可降低人内皮细胞的活力、迁移和功能。
Ponatinib hydrochloride (AP24534 hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.
体内研究：
Ponatinib hydrochloride (溶解于 25 mM 柠檬酸缓冲液 (pH 2.75) 中，体积 200 μL, 口服) 通过抑制细胞因子风暴保护小鼠免受致命流感感染。Animal Model:Influenza A Virus Infected Mice
Dosage:200 μL, dissolved in 25 mM citrate buffer (pH 2.75)
Administration:p.o.
Result:Had higher survival rates and reduced the infiltration of neutrophils.
体外研究：
Ponatinib hydrochloride (0.11, 017 μM, 24-48 h) 可降低人内皮细胞的活力、迁移和功能。
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