产品
编 号：F338742
分子式：C10H8N2O2S2
分子量：252.31
分子式：C10H8N2O2S2
分子量：252.31
产品类型
规格
价格
是否有货
5mg
100
In-stock
10mg
128
In-stock
结构图
CAS No: 3696-28-4
产品详情
生物活性：
Dipyrithione is a potent antimicrobial agent. Dipyrithione shows antifungal activity and antiproliferative activity. Dipyrithione induces apoptosis and cycle arrest at G1 phase. Dipyrithione shows anti-inflammatory activity in vivo. Dipyrithione shows anti-tumor activity. Dipyrithione has the potential for the research of dermatophytosis.
体内研究：
Dipyrithione (0.2 mg/cm2; externally once daily for 10 days) shows great anti-dermatophyte activity effects in guinea pig.Dipyrithione (1, 2.5, 5 mg/kg; i.p.) shows anti-inflammatory activity in mouse.Dipyrithione (5 mg/kg; i.p.; daily for 10 days) shows anti-tumor acyivity in mouse.Animal Model:Guinea pig (infected with Trichophyton rubrum)
Dosage:0.2 mg/cm2
Administration:Externally once daily for 10 days
Result:Showed normal hair growth, with no scaly skin.
Animal Model:18-22g male ICR mice2
Dosage:1, 2.5, 5 mg/kg
Administration:I.p.
Result:Raised the survival rate from 10% to 30%, 60% and 90%, respectively.
Animal Model:6 weeks, 18-20 g male ICR mice (hepatoma 22 (H22) cells)
Dosage:2.5 mg/kg
Administration:I.p.; daily for 10 days
Result:Inhibited the growth of tumor.
体外研究：
Dipyrithione (20?μg/mL) shows antifungal activity with MIC values of 6.03 μM for Trichophyton rubrum.Dipyrithione (72 h) shows cytotoxic activity against 293?T cells with an IC50 value of 0.22 μM.Dipyrithione (1-5 μM; 8.5 h) inhibits LPS (100 ng/ml)-induced up-regulation of iNOS and COX-2 in RAW264.7 cells in a dose-dependent manner.Dipyrithione (1 μM; 8.5 h) suppresses LPS-induced increase of iNOS but not COX-2 mRNA level, inhibits LPS-increased NO production.Dipyrithione (3 μM; 2, 5 h) decreases phosphorylation of STAT1 induced by LPS and does not influence LPS-induced MAPK and NF-κB activation in RAW 246.7 cells.Dipyrithione (0-5 μg/mL; 48 h) shows antiproliferative activity for KB, 231, U937 and K562 cells in a dose dependent manner.Dipyrithione (2.5 μg/ml) induces apoptosis and cycle arrest at G1 phase.
Dipyrithione is a potent antimicrobial agent. Dipyrithione shows antifungal activity and antiproliferative activity. Dipyrithione induces apoptosis and cycle arrest at G1 phase. Dipyrithione shows anti-inflammatory activity in vivo. Dipyrithione shows anti-tumor activity. Dipyrithione has the potential for the research of dermatophytosis.
体内研究：
Dipyrithione (0.2 mg/cm2; externally once daily for 10 days) shows great anti-dermatophyte activity effects in guinea pig.Dipyrithione (1, 2.5, 5 mg/kg; i.p.) shows anti-inflammatory activity in mouse.Dipyrithione (5 mg/kg; i.p.; daily for 10 days) shows anti-tumor acyivity in mouse.Animal Model:Guinea pig (infected with Trichophyton rubrum)
Dosage:0.2 mg/cm2
Administration:Externally once daily for 10 days
Result:Showed normal hair growth, with no scaly skin.
Animal Model:18-22g male ICR mice2
Dosage:1, 2.5, 5 mg/kg
Administration:I.p.
Result:Raised the survival rate from 10% to 30%, 60% and 90%, respectively.
Animal Model:6 weeks, 18-20 g male ICR mice (hepatoma 22 (H22) cells)
Dosage:2.5 mg/kg
Administration:I.p.; daily for 10 days
Result:Inhibited the growth of tumor.
体外研究：
Dipyrithione (20?μg/mL) shows antifungal activity with MIC values of 6.03 μM for Trichophyton rubrum.Dipyrithione (72 h) shows cytotoxic activity against 293?T cells with an IC50 value of 0.22 μM.Dipyrithione (1-5 μM; 8.5 h) inhibits LPS (100 ng/ml)-induced up-regulation of iNOS and COX-2 in RAW264.7 cells in a dose-dependent manner.Dipyrithione (1 μM; 8.5 h) suppresses LPS-induced increase of iNOS but not COX-2 mRNA level, inhibits LPS-increased NO production.Dipyrithione (3 μM; 2, 5 h) decreases phosphorylation of STAT1 induced by LPS and does not influence LPS-induced MAPK and NF-κB activation in RAW 246.7 cells.Dipyrithione (0-5 μg/mL; 48 h) shows antiproliferative activity for KB, 231, U937 and K562 cells in a dose dependent manner.Dipyrithione (2.5 μg/ml) induces apoptosis and cycle arrest at G1 phase.
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