产品
编 号：F338574
分子式：C12H12IN
分子量：297.14
分子式：C12H12IN
分子量：297.14
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
312
In-stock
10mg
444
In-stock
25mg
800
In-stock
50mg
1120
In-stock
100mg
1600
In-stock
结构图
CAS No: 36913-39-0
产品详情
生物活性：
MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT).
体外研究：
MPP+ (1-3 mM；24 小时) 显著降低细胞活力。MPP+ 还抑制线粒体制剂中烟酰胺腺苷二核苷酸 (NADH) 相关呼吸的活性，损害有氧糖酵解，导致目前认为抑制 NADH 相关细胞呼吸可能构成 MPP+ 神经毒性的最终分子机制。
MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT).
体外研究：
MPP+ (1-3 mM；24 小时) 显著降低细胞活力。MPP+ 还抑制线粒体制剂中烟酰胺腺苷二核苷酸 (NADH) 相关呼吸的活性，损害有氧糖酵解，导致目前认为抑制 NADH 相关细胞呼吸可能构成 MPP+ 神经毒性的最终分子机制。
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