产品
编 号：F338432
分子式：C3H9NO3S
分子量：139.17
分子式：C3H9NO3S
分子量：139.17
产品类型
规格
价格
是否有货
500mg
280
In-stock
1g
320
In-stock
5g
760
In-stock
结构图
CAS No: 3687-18-1
产品详情
生物活性：
Tramiprosate (Homotaurine), an orally active and brain-penetrant natural amino acid found in various species of red marine algae. Tramiprosate binds to soluble Aβ and maintains Aβ in a non-fibrillar form. Tramiprosate is also a GABA analog and possess neuroprotection, anticonvulsion and antihypertension effects.
体内研究：
Tramiprosate (6.25-50 mg/kg; intraperitoneal injection; once) treatment dose-dependently reduces the infarct volume after MCAO. Tramiprosate (50 mg/kg) treatment shows a significant neurological functional recovery.Animal Model:Adult male Sprague-Dawley rats (200-250 g) subjected to middle cerebral artery occlusion (MCAO)
Dosage:50 mg/kg, 25 mg/kg, 12.5 mg/kg or 6.25 mg/kg
Administration:Intraperitoneal injection; once
Result:Dose-dependently reduced the infarct volume after MCAO.
体外研究：
Tramiprosate (200 μg/mL, 40 μg/mL, 8 μg/mL and 1.6 μg/mL; 1 hours) significantly attenuates oxygen/glucose deprivation (OGD)- or NMDA-induced injury in NGF-differentiated PC12 cells and primary cortical neurons. Tramiprosate decreases the intensity of the association between nNOS and PSD95, and Tramiprosate also inhibits the translocation of nNOS from the cytosol to the membrane.
Tramiprosate (Homotaurine), an orally active and brain-penetrant natural amino acid found in various species of red marine algae. Tramiprosate binds to soluble Aβ and maintains Aβ in a non-fibrillar form. Tramiprosate is also a GABA analog and possess neuroprotection, anticonvulsion and antihypertension effects.
体内研究：
Tramiprosate (6.25-50 mg/kg; intraperitoneal injection; once) treatment dose-dependently reduces the infarct volume after MCAO. Tramiprosate (50 mg/kg) treatment shows a significant neurological functional recovery.Animal Model:Adult male Sprague-Dawley rats (200-250 g) subjected to middle cerebral artery occlusion (MCAO)
Dosage:50 mg/kg, 25 mg/kg, 12.5 mg/kg or 6.25 mg/kg
Administration:Intraperitoneal injection; once
Result:Dose-dependently reduced the infarct volume after MCAO.
体外研究：
Tramiprosate (200 μg/mL, 40 μg/mL, 8 μg/mL and 1.6 μg/mL; 1 hours) significantly attenuates oxygen/glucose deprivation (OGD)- or NMDA-induced injury in NGF-differentiated PC12 cells and primary cortical neurons. Tramiprosate decreases the intensity of the association between nNOS and PSD95, and Tramiprosate also inhibits the translocation of nNOS from the cytosol to the membrane.
产品资料
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