产品
编 号：F338035
分子式：C13H13Cl2N3O3
分子量：330.17
分子式：C13H13Cl2N3O3
分子量：330.17
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
250mg
400
In-stock
结构图
CAS No: 36734-19-7
产品详情
生物活性：
Iprodione is an orally active diformimide fungicide. Iprodione can specifically cause oxidative damage by producing free radicals (ROS). Iprodione is also an antiandrogen agent that delays adolescent development in rats and reduces sexual behavior and reproductive ability in rats.
体内研究：
Iprodione ( 200 mg/kg，口服;一天一次连续 65 天) 会降低大鼠的性行为和生育能力。Iprodione (50-200 mg/kg，灌胃给药;一天一次连续 30 天) 在发育未成熟的雄性 Sprague Dawley 大鼠中会延缓大鼠青春期发育，抑制睾丸内的类固醇生成。Animal Model:Adult male Sprague Dawley rats model
Dosage:200 mg/kg
Administration:Oral gavage (p.o.); Once daily for 65 days.
Result:Decreased the gonad index, sperm motility percentage and sperm count in mice.Reduced serum levels of testosterone, LH, FSH, and E2.Promoted steroidogenic genes downregulation and suppressed SIRT1/TERT/PGC1α pathway.
Animal Model:Weanling Sprague Dawley rats model
Dosage:50 mg/kg, 100 mg/kg, 200 mg/kg
Administration:Gavage (i.g.); Once daily for 30 days
Result:Delay PPS at 100 and 200 mg/kg.Reduced androgen-sensitive seminal vesicle and epididymis weight at 200 mg/kg.Increased adrenal and liver weight at a dose of 200 mg/kg.Reduced the production of testosterone and progesterone.
体外研究：
Iprodione (0.75-3 μM) 在液体和固体培养基中3 μM 的浓度下可以完全抑制菌核菌的菌丝生长，EC50 分别为 0.6 和 0.9 μM。Iprodione ( 1.5-50 μM; 1-6 天) 能抑制灰葡萄孢菌的生长，(5-50; 24 h) 可以抑制葡萄孢菌中脂质的合成。Iprodione (0.3-0.4 mM; 24 h) 通过增加鳟鱼肝细胞中的自由基 (ROS) 而产生氧化损伤且不具有物种选择性。
Iprodione is an orally active diformimide fungicide. Iprodione can specifically cause oxidative damage by producing free radicals (ROS). Iprodione is also an antiandrogen agent that delays adolescent development in rats and reduces sexual behavior and reproductive ability in rats.
体内研究：
Iprodione ( 200 mg/kg，口服;一天一次连续 65 天) 会降低大鼠的性行为和生育能力。Iprodione (50-200 mg/kg，灌胃给药;一天一次连续 30 天) 在发育未成熟的雄性 Sprague Dawley 大鼠中会延缓大鼠青春期发育，抑制睾丸内的类固醇生成。Animal Model:Adult male Sprague Dawley rats model
Dosage:200 mg/kg
Administration:Oral gavage (p.o.); Once daily for 65 days.
Result:Decreased the gonad index, sperm motility percentage and sperm count in mice.Reduced serum levels of testosterone, LH, FSH, and E2.Promoted steroidogenic genes downregulation and suppressed SIRT1/TERT/PGC1α pathway.
Animal Model:Weanling Sprague Dawley rats model
Dosage:50 mg/kg, 100 mg/kg, 200 mg/kg
Administration:Gavage (i.g.); Once daily for 30 days
Result:Delay PPS at 100 and 200 mg/kg.Reduced androgen-sensitive seminal vesicle and epididymis weight at 200 mg/kg.Increased adrenal and liver weight at a dose of 200 mg/kg.Reduced the production of testosterone and progesterone.
体外研究：
Iprodione (0.75-3 μM) 在液体和固体培养基中3 μM 的浓度下可以完全抑制菌核菌的菌丝生长，EC50 分别为 0.6 和 0.9 μM。Iprodione ( 1.5-50 μM; 1-6 天) 能抑制灰葡萄孢菌的生长，(5-50; 24 h) 可以抑制葡萄孢菌中脂质的合成。Iprodione (0.3-0.4 mM; 24 h) 通过增加鳟鱼肝细胞中的自由基 (ROS) 而产生氧化损伤且不具有物种选择性。
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