产品
编 号：F337146
分子式：C16H24ClNO
分子量：281.82
分子式：C16H24ClNO
分子量：281.82
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
250
In-stock
10mg
400
In-stock
50mg
560
In-stock
结构图
CAS No: 3644-61-9
产品详情
生物活性：
Tolperisone hydrochloride is a centrally acting muscle relaxant studied in neurological disorders causing pathological rhabdomyosclerosis (pyramidal tract injury, multiple sclerosis, myelopathy, encephalomyelitis), spastic paralysis, and other muscle dystonia-related Encephalopathy. Tolperisone hydrochloride also has antiviral activity.
体内研究：
Tolperisone (25-100 mg/kg) 对部分坐骨神经结扎 (pSNL) 诱发的神经性疼痛大鼠具有抗伤害作用。Tolperisone (60 mg/kg，每天一次，持续 1 周) 抑制 A375 细胞来源的异种移植瘤小鼠模型中的肿瘤生长。Animal Model:rats with partial sciatic nerve ligation (pSNL) evoked neuropathic pain
Dosage:25-100 mg/kg
Administration:p.o.
Result:Restored the developed mechanical allodynia 60, 120, and 180 min after treatment.Reduced elevated Cerebrospinal Fluid (CSF) glutamate level.
体外研究：
Tolperisone (0-128 μM, 48 h) hydrochloride 通过直接靶向 LSD1 诱导 UPR 介导的癌细胞死亡，IC50s 为 10-40 μM。 Tolperisone 抑制 LSD1 活性，IC50 为 31.09 μM。Tolperisone (100 μM，48 小时) 可诱导 AGS、A375、8505C 和 RKO 细胞中的癌细胞周期停滞和凋亡。Tolperisone (100 μM，12 小时) hydrochloride 使 M2 巨噬细胞重新极化为 M1 表型。
Tolperisone hydrochloride is a centrally acting muscle relaxant studied in neurological disorders causing pathological rhabdomyosclerosis (pyramidal tract injury, multiple sclerosis, myelopathy, encephalomyelitis), spastic paralysis, and other muscle dystonia-related Encephalopathy. Tolperisone hydrochloride also has antiviral activity.
体内研究：
Tolperisone (25-100 mg/kg) 对部分坐骨神经结扎 (pSNL) 诱发的神经性疼痛大鼠具有抗伤害作用。Tolperisone (60 mg/kg，每天一次，持续 1 周) 抑制 A375 细胞来源的异种移植瘤小鼠模型中的肿瘤生长。Animal Model:rats with partial sciatic nerve ligation (pSNL) evoked neuropathic pain
Dosage:25-100 mg/kg
Administration:p.o.
Result:Restored the developed mechanical allodynia 60, 120, and 180 min after treatment.Reduced elevated Cerebrospinal Fluid (CSF) glutamate level.
体外研究：
Tolperisone (0-128 μM, 48 h) hydrochloride 通过直接靶向 LSD1 诱导 UPR 介导的癌细胞死亡，IC50s 为 10-40 μM。 Tolperisone 抑制 LSD1 活性，IC50 为 31.09 μM。Tolperisone (100 μM，48 小时) 可诱导 AGS、A375、8505C 和 RKO 细胞中的癌细胞周期停滞和凋亡。Tolperisone (100 μM，12 小时) hydrochloride 使 M2 巨噬细胞重新极化为 M1 表型。
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