产品
编 号：F336886
分子式：C16H14O3
分子量：254.28
分子式：C16H14O3
分子量：254.28
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
240
In-stock
结构图
CAS No: 36330-85-5
产品详情
生物活性：
Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor.
体内研究：
Fenbufenmay (1200 mg/kg; feed) does not cause gastric ulceration whilst inducing a near maximal inhibition of prostaglandin release in rats.Fenbufenmay (1200 mg/kg; p.o.; diet; for 10 days) blocks the hypertrophy of the heart but not that of the skeletal muscles.Animal Model:Male hooded Lister rats
Dosage:1200 mg/kg
Administration:Oral administration, diet, for 10 days
Result:Significantly reduced Clenbuterol (2mg/kg)-induced hypertrophy of the heart.
体外研究：
Fenbufen (100-500 μM) improves the viability of apoptotic THP-1 cells treated with 25 μM Nigericin (HY-127019).
Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor.
体内研究：
Fenbufenmay (1200 mg/kg; feed) does not cause gastric ulceration whilst inducing a near maximal inhibition of prostaglandin release in rats.Fenbufenmay (1200 mg/kg; p.o.; diet; for 10 days) blocks the hypertrophy of the heart but not that of the skeletal muscles.Animal Model:Male hooded Lister rats
Dosage:1200 mg/kg
Administration:Oral administration, diet, for 10 days
Result:Significantly reduced Clenbuterol (2mg/kg)-induced hypertrophy of the heart.
体外研究：
Fenbufen (100-500 μM) improves the viability of apoptotic THP-1 cells treated with 25 μM Nigericin (HY-127019).
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