产品
编 号：F336468
分子式：C18H22O3
分子量：286.37
分子式：C18H22O3
分子量：286.37
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规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 362-06-1
产品详情
生物活性：
2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic.
体内研究：
Levels of both 2-Hydroxyestrone (2-OHE1; 2 mg/kg; administered ip.)?and ?2-Hydroxyestrone 4-N-acetylcysteine thioether (2-OHE1?4SR) in rats treated with 2-Hydroxyestrone?were significantly different between the induced and noninduced groups.Animal Model:Female and male Sprague-Dawley rats (6 weeks old)
Dosage:2 mg/kg
Administration:Administered i.p.
Result:Levels of both 2-OHE1?and ?2-OHE1?4SR in rats treated with 2-OHE1?were significantly different between the induced and noninduced groups.
体外研究：
2-Hydroxyestrone exhibits antiestrogen action on MCF-7 human breast cancer cells. Addition of 2-Hydroxyestrone to the cell cultures in concentration of 1-1000 nM has no effect on cell growth and proliferation because of rapid O-methylation of the catechol estrogen by catechol O-methyltransferase which is highly active in these cells. In the presence of quinalizarin, a potent catechol O-methyltransferase inhibitor which reduces the O-methylation of the steroid, 10 and 100 nM 2-Hydroxyestrone markedly suppresses the growth and proliferation of the cells.
2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic.
体内研究：
Levels of both 2-Hydroxyestrone (2-OHE1; 2 mg/kg; administered ip.)?and ?2-Hydroxyestrone 4-N-acetylcysteine thioether (2-OHE1?4SR) in rats treated with 2-Hydroxyestrone?were significantly different between the induced and noninduced groups.Animal Model:Female and male Sprague-Dawley rats (6 weeks old)
Dosage:2 mg/kg
Administration:Administered i.p.
Result:Levels of both 2-OHE1?and ?2-OHE1?4SR in rats treated with 2-OHE1?were significantly different between the induced and noninduced groups.
体外研究：
2-Hydroxyestrone exhibits antiestrogen action on MCF-7 human breast cancer cells. Addition of 2-Hydroxyestrone to the cell cultures in concentration of 1-1000 nM has no effect on cell growth and proliferation because of rapid O-methylation of the catechol estrogen by catechol O-methyltransferase which is highly active in these cells. In the presence of quinalizarin, a potent catechol O-methyltransferase inhibitor which reduces the O-methylation of the steroid, 10 and 100 nM 2-Hydroxyestrone markedly suppresses the growth and proliferation of the cells.
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