产品
编 号:F336280
分子式:C21H22O6
分子量:370.4
产品类型
结构图
CAS No: 36150-23-9
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产品详情
生物活性:
Kobusin is a bisepoxylignan isolated from the Pnonobio biondii Pamp. Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel.
体内研究:
In charcoal transit study, Kobusin mildly reduced gastrointestinal motility in mice.
体外研究:
Kobusin could activate the function of CFTR and CaCCgie (CaCC expressed in gastrointestinal epithelial cells) chloride channels. Notably, Kobusin could inhibit the activities ANO1/CaCC chloride channel in ANO1/CaCC-expressing FRT cells.