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编 号：F038690
分子式：C21H33N2O6P
分子量：440.47
分子式：C21H33N2O6P
分子量：440.47
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CAS No: 111223-26-8
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生物活性：
Ceronapril (SQ 29852) is a potent and orally active angiotensin converting enzyme (ACE) inhibitor with an IC50 of 36 nM.
体内研究：
Ceronapril (SQ 29852) 在雄性 SD 大鼠中抑制 ACE，静脉注射和口服的 ED50 分别为 0.063 μM/kg 和 0.53 μM/kg。Ceronapril (100 mg/kg; p.o.; single dose or twice daily for 3 days) 阻断大鼠外周部位的 ACE 。Animal Model:Male Sprague-Dawley rats
Dosage:100 mg/kg
Administration:PO, twice daily for 3 days or single daily dose
Result:Showed clear inhibition of ACE in the 2 circumventricular organs-the subfornical organ and the lamina terminals-but no change in other regions of the brain after chronic treatment. Inhibited ACE in plasma, kidney and lung rapidly (3 hr) after a single administration. Did not inhibit ACE in structures of the brain within the blood-brain barrier, such as the caudate-putamen, choroid plexus, globus pallidus, supraoptic nucleus and paraventricular nucleus of the hypothalamus.
Ceronapril (SQ 29852) is a potent and orally active angiotensin converting enzyme (ACE) inhibitor with an IC50 of 36 nM.
体内研究：
Ceronapril (SQ 29852) 在雄性 SD 大鼠中抑制 ACE，静脉注射和口服的 ED50 分别为 0.063 μM/kg 和 0.53 μM/kg。Ceronapril (100 mg/kg; p.o.; single dose or twice daily for 3 days) 阻断大鼠外周部位的 ACE 。Animal Model:Male Sprague-Dawley rats
Dosage:100 mg/kg
Administration:PO, twice daily for 3 days or single daily dose
Result:Showed clear inhibition of ACE in the 2 circumventricular organs-the subfornical organ and the lamina terminals-but no change in other regions of the brain after chronic treatment. Inhibited ACE in plasma, kidney and lung rapidly (3 hr) after a single administration. Did not inhibit ACE in structures of the brain within the blood-brain barrier, such as the caudate-putamen, choroid plexus, globus pallidus, supraoptic nucleus and paraventricular nucleus of the hypothalamus.
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