产品
编 号：F335420
分子式：C25H32O12
分子量：524.51
分子式：C25H32O12
分子量：524.51
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 35897-92-8
产品详情
生物活性：
Ligustroside (Ligstroside), a secoiridoid derivative, has outstanding performance on mitochondrial bioenergetics in models of early Alzheimer's disease (AD) and brain ageing by mechanisms that may not interfere with Aβ production. Ligustroside significantly inhibits nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophages.
体内研究：
Ligstroside (50 mg/kg; a supplemented diet for 6 months) protects against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing.Animal Model:Female NMRI mice, aged 12 months
Dosage:50 mg/kg
Administration:Received a supplemented diet for 6 months (equivalent to 6.25 mg/kg b.w.)
Result:Showed improved spatial working memory; Restored brain ATP levels in aged mice and led to a significant life extension compared to aged control animals.
体外研究：
Ligstroside increases mRNA expression of SIRT1, CREB1, complex I, and GPx1 in SH-SY5Y-APP695 cells.
Ligustroside (Ligstroside), a secoiridoid derivative, has outstanding performance on mitochondrial bioenergetics in models of early Alzheimer's disease (AD) and brain ageing by mechanisms that may not interfere with Aβ production. Ligustroside significantly inhibits nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophages.
体内研究：
Ligstroside (50 mg/kg; a supplemented diet for 6 months) protects against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing.Animal Model:Female NMRI mice, aged 12 months
Dosage:50 mg/kg
Administration:Received a supplemented diet for 6 months (equivalent to 6.25 mg/kg b.w.)
Result:Showed improved spatial working memory; Restored brain ATP levels in aged mice and led to a significant life extension compared to aged control animals.
体外研究：
Ligstroside increases mRNA expression of SIRT1, CREB1, complex I, and GPx1 in SH-SY5Y-APP695 cells.
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