产品
编 号：F335390
分子式：C21H39NO6
分子量：401.54
分子式：C21H39NO6
分子量：401.54
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 35891-70-4
产品详情
生物活性：
Myriocin (Thermozymocidin), a fungal metabolite could be isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia, is a potent inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin suppresses replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC50 of 3.5 μg/mL for inhibiting HCV infection.
体内研究：
Myriocin (Thermozymocidin; 0-1 mg/kg; i.p.; daily, for 5 d; male Balb/c mice) blocks de novo synthesis of sphingolipids in vivo by SPT inhibition and induced c-myc expression in liver.Animal Model:Male Balb/c mice (22 g, 7-8 weeks old)
Dosage:0, 0.1, 0.3, and 1.0 mg/kg
Administration:Intraperitoneal injection; daily, for 5 days
Result:Altered not significantly the levels of plasma alanine aminotransferase and aspartate aminotransferase.Decreased free sphinganine in a dose-dependent manner in both the liver and kidney.Decreased in the activity of liver SPT with a correlation coefficient of -0.76.Increased the expression of liver c-myc in a dose-dependent manner.
体外研究：
Myriocin (Thermozymocidin; 0-10000 nM; 96 h; Huh7/Rep-Feo cells) inhibits the replication of a subgenomic hepatitis C virus (HCV) genotype 1b replicon.Myriocin (100 nM; 72 h) decreases in the sphingomyelin content of Huh7 cells.
Myriocin (Thermozymocidin), a fungal metabolite could be isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia, is a potent inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin suppresses replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC50 of 3.5 μg/mL for inhibiting HCV infection.
体内研究：
Myriocin (Thermozymocidin; 0-1 mg/kg; i.p.; daily, for 5 d; male Balb/c mice) blocks de novo synthesis of sphingolipids in vivo by SPT inhibition and induced c-myc expression in liver.Animal Model:Male Balb/c mice (22 g, 7-8 weeks old)
Dosage:0, 0.1, 0.3, and 1.0 mg/kg
Administration:Intraperitoneal injection; daily, for 5 days
Result:Altered not significantly the levels of plasma alanine aminotransferase and aspartate aminotransferase.Decreased free sphinganine in a dose-dependent manner in both the liver and kidney.Decreased in the activity of liver SPT with a correlation coefficient of -0.76.Increased the expression of liver c-myc in a dose-dependent manner.
体外研究：
Myriocin (Thermozymocidin; 0-10000 nM; 96 h; Huh7/Rep-Feo cells) inhibits the replication of a subgenomic hepatitis C virus (HCV) genotype 1b replicon.Myriocin (100 nM; 72 h) decreases in the sphingomyelin content of Huh7 cells.
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