产品
编 号:F333619
分子式:C13H8O6
分子量:260.2
产品类型
结构图
CAS No: 3542-72-1
联系客服
产品详情
生物活性:
Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC50 of 3.12?μM. Norathyriol inhibits PPARα, PPARβ, and PPARγ with IC50s of 92.8 μM, 102.4 μM, and 153.5 μM, respectively. Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.
体内研究:
Norathyriol is a natural metabolite of Mangifera in the human intestine with the oral availability and safety. Norathyriol (0.92, 1.85 and 3.7?mg/kg) dose dependently decreased the serum urate levels by 27.0, 33.6 and 37.4%, respectively.Animal Model:Adult Kunming mice weighing 18-22?g
Dosage:0.92, 1.85 and 3.7?mg/kg
Administration:Administered intragastrically; twice daily for five times
Result:The serum uric acid levels were decreased by 27.0%, 33.6% and 37.4%.
体外研究:
Norathyriol (1-25 μM) inhibits growth by inducing cell cycle arrest in JB6 P+ cells. Norathyriol inhibits JB6 cell growth by inducing G2-M arrest.Norathyriol suppresses UVB-induced phosphorylation of ERKs, AP-1 and NF-κB activation in JB6 P+ cellsCell Growth Assay WB