产品
编 号：F332185
分子式：C21H18N2O3S
分子量：378.44
分子式：C21H18N2O3S
分子量：378.44
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 351353-48-5
产品详情
生物活性：
DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC50 of 30 nM.
体内研究：
DPTIP potently (10?mg/kg IP) inhibits IL-1β-induced astrocyte-derived EV release.Animal Model:Mice.
Dosage:10?mg/kg.
Administration:IP 0.5?h prior to IL-1β striatal injection.
Result:Brain concentrations of DPTIP are above its IC50 for nSMase2 inhibition for at least 4?h after compound administration.The number of astrocyte-derived EVs was reduced by 51?±?13% 2?h post IL-1β administration.
体外研究：
DPTIP blocks EV secretion in a dose dependent manner (0.03-30 μM), and at 30 μM, this compound could decrease exosome release by 50% in astrocytes.
DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC50 of 30 nM.
体内研究：
DPTIP potently (10?mg/kg IP) inhibits IL-1β-induced astrocyte-derived EV release.Animal Model:Mice.
Dosage:10?mg/kg.
Administration:IP 0.5?h prior to IL-1β striatal injection.
Result:Brain concentrations of DPTIP are above its IC50 for nSMase2 inhibition for at least 4?h after compound administration.The number of astrocyte-derived EVs was reduced by 51?±?13% 2?h post IL-1β administration.
体外研究：
DPTIP blocks EV secretion in a dose dependent manner (0.03-30 μM), and at 30 μM, this compound could decrease exosome release by 50% in astrocytes.
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