产品
编 号：F331432
分子式：C26H30O6
分子量：438.51
分子式：C26H30O6
分子量：438.51
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 34981-25-4
产品详情
生物活性：
Kuraridine is a prenylated flavonol extract from the roots of?Sophora flavescens. Kuraridine has an inhibitory effect on cGMP specific phosphodiesterase type 5?(PDE5) (IC50=0.64 μM).
体外研究：
Kuraridine shows potent inhibitory activity (IC50=0.64 μM) against cGMP PDE5 with 2.0- and 12.9-fold selectivity over PDE3 and PDE4, respectively.Kuraridine induces pronounced chloride inward currents in the absence of GABA. Thecurrents does not exceed 10% of the maximal?IGABA?induced by a saturating GABA concentration (1 mM).Kuraridine induces a concentration–response curves for?IGABA?enhancement (EC50=4.0±2.4 μM) in Xenopus?oocytes expressing GABAA?receptors composed of?α1, β2, and?γ2S?subunits.
Kuraridine is a prenylated flavonol extract from the roots of?Sophora flavescens. Kuraridine has an inhibitory effect on cGMP specific phosphodiesterase type 5?(PDE5) (IC50=0.64 μM).
体外研究：
Kuraridine shows potent inhibitory activity (IC50=0.64 μM) against cGMP PDE5 with 2.0- and 12.9-fold selectivity over PDE3 and PDE4, respectively.Kuraridine induces pronounced chloride inward currents in the absence of GABA. Thecurrents does not exceed 10% of the maximal?IGABA?induced by a saturating GABA concentration (1 mM).Kuraridine induces a concentration–response curves for?IGABA?enhancement (EC50=4.0±2.4 μM) in Xenopus?oocytes expressing GABAA?receptors composed of?α1, β2, and?γ2S?subunits.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备