产品
编 号：F331015
分子式：C16H19NO3S
分子量：305.39
分子式：C16H19NO3S
分子量：305.39
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
400
In-stock
10mg
640
In-stock
25mg
1200
In-stock
50mg
1920
In-stock
100mg
3080
In-stock
结构图
CAS No: 349085-82-1
产品详情
生物活性：
GSK137647A (GSK 137647) is a potent, selective free fatty acid receptor 4 (FFA4) agonist with pEC50 values of 6.3, 6.2, and 6.1 for human, mouse and rat FFA4, and pEC50 values < 4.5 for all three species for FFA1, FFA2, and FFA3, respectively. GSK137647A has anti-inflammatory activity. GSK137647A induces insulin secretion and inhibits epithelial ion transport, GSK137647A is related to regulation of glucose homeostasis and anti-inflammatory response.
体内研究：
GSK137647A (GSK 137647) (1 mg/kg; i.p.; twice daily, for 7 days; C57BL/6 mice) alleviates colitis in TNBS- and DSS-treated mice.GSK137647A (GSK 137647) (1 mg/kg; i.p.; twice daily, for 7 days; C57BL/6 mice) restores intestinal permeability in vivo.Animal Model:Male C57BL/6 mice
Dosage:1 mg/kg
Administration:Intraperitoneal injection; twice daily, for 7 days
Result:Had anti-inflammatory effect and reversed colonic injury induced by DSS.
Animal Model:Male C57BL/6 mice
Dosage:1 mg/kg
Administration:Intraperitoneal injection; twice daily, for 7 days
Result:Decreased the amount of FITC and alleviated intestinal epithelial barrier permeability.
体外研究：
GSK137647A (GSK 137647) (50 μM) reduces the production of NO in macrophages without affecting cell viability.GSK137647A (GSK 137647) (30 μM; 12 hours) alleviates response to inflammatory stimuli in Caco-2 cells and induces secretion of IL-6.GSK137647A (GSK 137647) (10 μM) reduces the ion flow and affects the colonic epithelial ion transport in healthy. GSK137647A (GSK 137647) (50 μM) increases glucose stimulated insulin secretion.
GSK137647A (GSK 137647) is a potent, selective free fatty acid receptor 4 (FFA4) agonist with pEC50 values of 6.3, 6.2, and 6.1 for human, mouse and rat FFA4, and pEC50 values < 4.5 for all three species for FFA1, FFA2, and FFA3, respectively. GSK137647A has anti-inflammatory activity. GSK137647A induces insulin secretion and inhibits epithelial ion transport, GSK137647A is related to regulation of glucose homeostasis and anti-inflammatory response.
体内研究：
GSK137647A (GSK 137647) (1 mg/kg; i.p.; twice daily, for 7 days; C57BL/6 mice) alleviates colitis in TNBS- and DSS-treated mice.GSK137647A (GSK 137647) (1 mg/kg; i.p.; twice daily, for 7 days; C57BL/6 mice) restores intestinal permeability in vivo.Animal Model:Male C57BL/6 mice
Dosage:1 mg/kg
Administration:Intraperitoneal injection; twice daily, for 7 days
Result:Had anti-inflammatory effect and reversed colonic injury induced by DSS.
Animal Model:Male C57BL/6 mice
Dosage:1 mg/kg
Administration:Intraperitoneal injection; twice daily, for 7 days
Result:Decreased the amount of FITC and alleviated intestinal epithelial barrier permeability.
体外研究：
GSK137647A (GSK 137647) (50 μM) reduces the production of NO in macrophages without affecting cell viability.GSK137647A (GSK 137647) (30 μM; 12 hours) alleviates response to inflammatory stimuli in Caco-2 cells and induces secretion of IL-6.GSK137647A (GSK 137647) (10 μM) reduces the ion flow and affects the colonic epithelial ion transport in healthy. GSK137647A (GSK 137647) (50 μM) increases glucose stimulated insulin secretion.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备